目的 探讨结石通胶囊联合氨苄西林治疗尿路感染的临床疗效。方法 选取2020年7月-2023年6月蚌埠市第一人民医院收治的86例尿路感染患者,按随机数字表法将患者分为对照组和治疗组,每组各43例。对照组口服氨苄西林胶囊,3粒/次,3次/d。治疗组在对照组基础上口服结石通胶囊,4粒/次,3次/d。两组疗程均为7 d。观察两组临床疗效,比较两组退热时间、尿细菌培养转阴时间及治疗前后典型症状评分、36项健康调查简表(SF-36)评分和血清C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)水平。结果 治疗后,治疗组总有效率是97.67%,较之对照组的81.40%显著提高(P<0.05)。治疗后,两组尿痛评分、尿频评分、尿急评分、小腹不适评分均较同组治疗前显著降低(P<0.05);治疗后,治疗组典型症状评分低于对照组(P<0.05)。治疗组退热时间、尿细菌培养转阴时间均显著短于对照组(P<0.05)。治疗后,两组SF-36评分均显著增加,而血清CRP、PCT、IL-6水平均显著下降(P<0.05);且治疗后,治疗组SF-36评分高于对照组,血清CRP、PCT、IL-6水平低于对照组(P<0.05)。结论 结石通胶囊联合氨苄西林治疗尿路感染效果确切,可明显改善生活质量,同时能有效控制尿路感染症状,缩短尿细菌培养转阴时间,缓解机体炎症反应,值得临床推广应用。

Objective To explore the clinical efficacy of Jieshitong Capsules combined with ampicillin in treatment of urinary tract infection. Methods A total of 86 patients with urinary tract infection admitted to Bengbu First People's Hospital from July 2020 to June 2023 were selected and divided into control group and treatment group according to random number table method, with 43 cases in each group. Patients in the control group were po administered with Ampicillin Capsules, 3 grains/time, three times daily. Patients in the treatment group were po administered with Jieshitong Capsules on the basis of control group, 4 grains/time, 3 times daily. The treatment course of both groups was 7 d. After treatment, the clinical efficacy was evaluated, and the time for fever reduction, the time for urine bacterial culture to turn negative, and the typical symptom scores before and after treatment, as well as the scores of 36 health survey questionnaires (SF-36) and serum C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels were compared. Results After treatment, the total effective rate of the treatment group was 97.67%, which was significantly higher than that of the control group (81.40%) (P < 0.05). After treatment, the scores of urinalgia, frequency of urination, urgency of urination, and lower abdominal discomfort in 2 groups were significantly lower than before treatment (P < 0.05). After treatment, the typical symptom score of the treatment group was lower than that of control group (P < 0.05). The time of febrile degeneration and the time of urine bacterial culture turning negative in treatment group were significantly shorter than those in control group (P < 0.05). After treatment, SF-36 scores in both groups were significantly increased, but serum CRP, PCT, and IL-6 levels were significantly decreased (P < 0.05). After treatment, the SF-36 score of treatment group was higher than that of control group, but the levels of serum CRP, PCT and IL-6 were lower than those of the control group (P < 0.05). Conclusion Jieshitong Capsules combined with ampicillin has the exact effect in treatment of urinary tract infection, and can significantly improve the life quality, and can effectively control the symptoms of urinary tract infection, shorten the time of urinary bacterial culture to negative, relieve the body inflammatory response, which is worthy of clinical application.

R983

新疆维吾尔自治区自然科学基金资助项目（2017D01C102）