目的 探讨静灵口服液联合阿立哌唑片治疗儿童注意缺陷多动障碍的临床疗效。方法 选取2022年1月-2022年12月秦皇岛市第一医院收治的60例注意缺陷多动障碍患儿,经随机数字表法分为对照组和治疗组,每组各30例。对照组晚上口服阿立哌唑片,初始剂量1片/次,1次/d,用药2周后可以根据患儿的实际疗效和耐受情况逐渐增加药物剂量,最大剂量不超过3片/d。治疗组在对照组基础上口服静灵口服液,1支/次,2次/d。两组患儿均治疗8周。比较两组的治疗效果、症状情况、多动障碍、注意力、血清指标。结果 治疗组总有效率(93.33%)显著高于对照组总有效率(73.33%)(P<0.05)。治疗后,两组患儿注意力缺陷多动障碍评定量表(SNAP-IV)评分、Conners父母症状问卷评分和数字划消试验失误率均显著降低,血清催乳素(PRL)、中枢神经特异蛋白(S100β)、25-羟维生素D水平均显著升高(P<0.05),且治疗组各指标的变化明显优于对照组(P<0.05)。结论 静灵口服液联合阿立哌唑片治疗儿童注意缺陷多动障碍的临床效果显著,可以有效改善患儿的临床症状,提高注意力,调节血清因子。

Objective To explore the clinical therapeutic effect of Jingling Oral Liquid combined with Aripiprazole Tablets on attention deficit and hyperactivity disorder in children. Methods Children (60 cases) with attention deficit and hyperactivity disorder in First Hospital of Qinhuangdao from January 2022 to December 2022 were divided into control group (30 cases) and treatment group (30 cases) according to the random number table method. Children in the control group were po administered with Aripiprazole Tablets at night, initial dose 1 tablet/time, once daily, after 2 weeks of medication, the drug dosage gradually increased based on the actual efficacy and tolerance, with a maximum dose not exceeding 3 tablets daily. Children in the treatment group were po administered with Jingling Oral Liquid on the basis of the control group, 1 piece/time, twice daily. Children in two groups were treated for 8 weeks. The clinical efficacies, the symptoms, hyperactivity disorder, attention, and serum indicators in two groups were compared. Results The total effective rate of the treatment group (93.33%) was significantly higher than 73.33% of the control group (P < 0.05). After treatment, the SNAP-IV score, PSQ score and NCT error rate in two groups were significantly decreased, and serum PRL, S100-β, and 25-hydroxyvitamin D in two groups were significantly increased (P < 0.05), and the changes of indexes in treatment group were better than those in the control group (P < 0.05). Conclusion The clinical effect of Jingling oral liquid combined with Aripiprazole Tablets is significant, which can effectively improve the clinical symptoms of children and increase their attention, and regulate serum factors.

R971

秦皇岛市科学技术研究与发展计划项目（202101A128）