目的 探讨双黄连口服液联合喜炎平注射液治疗小儿疱疹性咽峡炎的临床效果。方法 选取2022年9月-2023年8月成都市龙泉驿区妇幼保健院收治的120例疱疹性咽峡炎患儿,采用随机数字表法将所有患者分为对照组和治疗组,每组各60例。对照组静脉滴注喜炎平注射液,0.4 mL/kg与生理盐水混合后静脉滴注,最大剂量不超过20 mL,1次/d。治疗组在对照组治疗基础上口服双黄连口服液,1岁 ≤ 患儿年龄<3岁,10 mL/次;3岁 ≤ 患儿年龄<7岁,20 mL/次,3次/d。两组均连续治疗5 d。观察两组临床疗效和体温至正常范围时间、咽痛消失时间,同时比较两组治疗前后中性粒细胞与淋巴细胞比值(NLR)及血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)。结果 治疗后,治疗组患儿总有效率是96.67%,显著高于对照组的86.67%(P<0.05)。治疗后,治疗组患儿体温至正常范围时间、咽痛消失时间均显著短于对照组(P<0.05)。治疗后,两组患儿的NLR及血清CRP、TNF-α水平较同组治疗前显著降低(P<0.05);治疗后,治疗组患儿NLR及血清CRP、TNF-α水平低于对照组(P<0.05)。结论 双黄连口服液联合喜炎平注射液治疗小儿疱疹性咽峡炎可获得较为理想的疗效,可迅速改善患儿的体温异常升高、咽痛等症状,对体内的炎症反应有明显的抑制作用,且无明显不良反应。

Objective To explore the efficacy of Shuanghuanglian Oral Liquid combined with Xiyanping Injection in treatment of herpetic angina in children. Methods A total of 120 children with herpetic angina treated in Chengdu Longquanyi District Maternal and Child Health Hospital from September 2022 to August 2023 were selected and divided into control group and treatment group by random number table method, with 60 cases in each group. Patients in the control group were iv administered with Xiyanping Injection, 0.4 mL/kg was mixed with normal saline and then injected intravenously, the maximum dosage was not more than 20 mL, once daily. Patients in the treatment group were po administered with Shuanghuanglian Oral Liquid on the basis of control group, 1 ≤ children age< 3 years old, 10 mL/time; 3 ≤ children nage < 7 years old, 20 mL/time, 3 times daily. Both groups were treated continuously for 5 d. The clinical efficacy, temperature to normal range time, throat pain disappearance time of two groups were observed, and the ratio of neutrophil to lymphocyte (NLR), serum C-reactive protein (CRP), and tumor necrosis faction-α (TNF-α) before and after treatment were compared between the two groups. Results After treatment, the total effective rate of treatment group was 96.67%, which was significantly higher than that of control group (86.67%, P < 0.05). After treatment, the temperature to normal range and the disappearance time of pharyngeal pain in treatment group were significantly shorter than those in control group (P < 0.05). After treatment, the levels of NLR and serum CRP and TNF-α in 2 groups were significantly decreased compared with those before treatment P < 0.05). After treatment, the levels of NLR, serum CRP and TNF-α in treatment group were lower than those in control group (P < 0.05). Conclusion Shuanghuanglian Oral Liquid combined with Xiyanping Injection can obtain ideal curative effect in treatment of herpetic angina in children, and can quickly improve the symptoms of abnormal temperature rise and sore throat in children, and has obvious inhibitory effect on inflammation in the body, which has no obvious adverse reactions

R974

四川省科技计划项目（2020YFS0275）