目的 探讨妇炎消胶囊联合甲硝唑片治疗细菌性阴道病的临床疗效。方法 选取2021年1月—2023年1月郑州市第七人民医院就诊120例的细菌性阴道病患者，按信封随机法分成对照组（60例）和治疗组（60例）。对照组口服甲硝唑片，2次/d，2片/次。治疗组在对照组基础上口服妇炎消胶囊治疗，3次/d，3粒/次。两组连续给药1周。比较两组的临床疗效、复发率、症状改善时间、氧化应激指标、炎症反应指标。结果 治疗后，治疗组总有效率（95.00%）高于对照组（83.33%），复发率（6.67%）低于对照组（20.00%），差异均有统计学意义（P＜0.05）。治疗后，治疗组阴道壁充血消失、白带异常、小便后灼热感、小腹胀痛和阴道口瘙痒改善时间短于对照组（P＜0.05）。治疗后，两组血清超氧化物歧化酶（SOD）水平升高，血清一氧化氮（NO）、丙二醛（MDA）、超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平下降（P＜0.05），且治疗组血清SOD水平高于对照组，血清NO、MDA、hs-CRP、IL-6和TNF-α水平低于对照组（P＜0.05）。结论 妇炎消胶囊联合甲硝唑片治疗细菌性阴道病的疗效显著，有利于缩短临床症状改善时间，改善氧化应激反应，降低炎症因子指标，预防疾病复发。

Objective To explore the clinical efficacy of Fuyanxiao Capsules combined with Metronidazole Tablets in treatment of bacterial vaginitis. Methods Patients (120 cases) with bacterial vaginitis in the 7th People's Hospital of Zhengzhou from January 2021 to January 2023 were divided into control and treatment groups according to the envelope randomization method, and each group had 60 cases. Patients in the control group were po administered with Metronidazole Tablets, 2 tablets/time, twice daily. Patients in the treatment group were po administered with Fuyanxiao Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 1 week. The clinical efficacies, recurrence rates, the symptom improvement time, oxidative stress indicators, and inflammatory response indicators in two groups were compared. Results After treatment, the effective rate of the treatment group (95.00%) was higher than 83.33% of the control group, and the recurrence rate (6.67%) was lower than 20.00% of the control group, with statistical significance between two groups (P < 0.05). After treatment, the improvement time of vaginal wall congestion, abnormal vaginal discharge, burning sensation after urination, lower abdominal distension, and itching at the vaginal opening in the treatment group was shorter than that in the control group (P < 0.05). After treatment, the serum levels of SOD in two groups increased but serum levels of NO, MDA, hs-CRP, IL-6, and TNF-α in two groups decreased (P < 0.05). The serum levels of SOD in the treatment group were higher than those in the control group, but serum levels of NO, MDA, hs-CRP, IL-6, and TNF-α in the treatment group were lower than those in the control group (P < 0.05). Conclusion Fuyanxiao Capsules combined with Metronidazole Tablets is effective in treatment of bacterial vaginitis, which is beneficial for shortening the time for clinical symptom improvement, improving oxidative stress response, reducing inflammatory factor indicators, and preventing disease recurrence.

R984

河南省医学科技攻关计划（联合共建）项目（LHGJ20191322）