目的 分析小儿热速清口服液联合环酯红霉素治疗小儿急性上呼吸道感染的临床疗效。方法 选取2022年1月—12月北京市通州区妇幼保健院收治的急性上呼吸道感染患儿116例，按随机数字表法将所有患者分为对照组和治疗组，每组各58例。对照组患儿口服环酯红霉素干混悬剂，15 mg/kg，每12 h给药1次，将本品加入适量凉开水溶解摇匀后口服。治疗组在对照组治疗基础上口服小儿热速清口服液，1≤年龄≤3岁、3岁＜年龄≤6岁、6岁＜年龄≤12岁者分别给予10、15、20 mL/次，3次/d。两组疗程是5 d。观察两组临床疗效、完全退热时间及其他症状消失时间。比较治疗前后两组儿童睡眠习惯问卷（CSHQ）、儿少主观生活质量问卷（ISLQ）评分及全血白细胞计数（WBC）、红细胞沉降率（ESR）、C反应蛋白（CRP）水平。结果 治疗后，治疗组总有效率是94.83%，与对照组的84.48%相比显著更高（P＜0.05）。治疗组完全退热时间和鼻塞、流涕、扁桃体肿大、全身酸痛、咽痛、咳嗽的消失时间均显著短于对照组（P＜0.05）。治疗后，两组CSHQ评分均显著降低，而ISLQ评分均显著增加（P＜0.05）；治疗后，治疗组CSHQ、ISLQ评分改善更显著（P＜0.05）。治疗后，两组全血WBC、ESR、CRP水平均显著下降（P＜0.05）；且治疗组降低更显著（P＜0.05）。结论 小儿热速清口服液联合环酯红霉素治疗小儿急性上呼吸道感染疗效确切，能加速患儿症状和体征的改善，降低睡眠和生活质量的受影响程度，值得临床推广应用。

Objective To analyze the clinical efficacy of Xiaoer Resuqing Oral Liquid combined with erythromycin cyclocarbonate in treatment of acute upper respiratory tract infection in children. Methods A total of 116 children with acute upper respiratory tract infection treated in Tongzhou District Maternal and Child Health Hospital of Beijing from January to December 2022 were selected and divided into control group and treatment group according to random number table method, with 58 cases in each group. Children in the control group were po administered with Erythromycin Cyclocarbonate for Suspension, 15 mg/kg, once every 12 h, dissolved it in cold water, shaked well, and then took it orally. Children in the treatment group were po administered with Xiaoer Resuqing Oral Liquid, 1 ≤ age ≤ 3 years old, 3 years old < age ≤ 6 years old, 6 years old < age ≤ 12 years old were given 10, 15, 20 mL/time, 3 times daily, respectively. Both groups were treated for 5 d. The clinical effect, the time of complete fever remission and the time of other symptoms disappearance were observed. The scores of Sleep habits Questionnaire (CSHQ), Subjective Quality of Life Questionnaire (ISLQ), whole blood white blood cell count (WBC), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were compared between two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 94.83%, which was significantly higher than that of the control group (84.48%) (P < 0.05). The time of complete remission of fever and the disappearance time of nasal obstruction, runny nose, swollen tonsils, aching body, sore throat and cough in treatment group were significantly shorter than those in control group (P < 0.05). After treatment, CSHQ score was significantly decreased, but ISLQ score was significantly increased in both groups (P < 0.05). After treatment, CSHQ and ISLQ scores in treatment group were significantly improved (P < 0.05). After treatment, whole blood WBC,ESR and CRP levels were significantly decreased in both groups (P < 0.05). The decrease was more significant in treatment group (P < 0.05). Conclusion Xiaoer Resuqing Oral Liquid combined with erythromycin cyclocarbonate has definite curative effect in treatment of acute upper respiratory tract infection in children, and can accelerate the improvement of children's symptoms and signs, reduce the sleep degree and life quality affected, which is worthy of clinical application.

R974

北京市卫生科技成果与适宜技术推广项目资助基金（2018-TG-69）