目的 探讨脑安滴丸联合丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效。方法 选取2022年1月—12月北京市隆福医院收治的146例急性脑梗死患者，按随机数字表法将所有患者分为对照组和治疗组，每组各73例。对照组静脉滴注丁苯酞氯化钠注射液，100 mL/次，2次/d，滴注时间≥50 min/次。治疗组在对照组基础上口服脑安滴丸，20粒/次，2次/d。两组疗程14 d。观察两组的临床疗效，比较治疗前后两组简式Fugl-Meyer评定量表（FMA）和美国国立卫生研究院卒中量表（NIHSS）评分、血栓及血小板参数及血清C反应蛋白（CRP）、一氧化氮（NO）、超氧化物歧化酶（SOD）、谷氨酸（Glu）水平。结果 治疗后，治疗组总有效率是95.89%，显著高于对照组的86.30%（P＜0.05）。治疗后，两组FMA评分均较治疗前显著升高，而NIHSS评分显著降低（P＜0.05）；治疗组FMA、NIHSS评分改善更显著（P＜0.05）。治疗后，两组血浆纤溶酶-抗纤溶酶复合物（PAP）、凝血酶抗凝血酶复合物（TAT）和血小板聚集率（PAgT）均较治疗前显著下降（P＜0.05）；且以治疗组下降更显著（P＜0.05）。治疗后，两组患者血清CRP、Glu水平均显著下降，而血清NO、SOD水平均显著上升（P＜0.05）；且治疗组血清CRP、NO、SOD、Glu水平改善更显著（P＜0.05）。结论 脑安滴丸联合丁苯酞氯化钠注射液治疗急性脑梗死可获得良好的疗效，能安全有效地抗血栓形成，缓解炎症及氧化应激损害，促进神经及运动功能改善。

Objective To explore the clinical efficacy of Naoan Dropping Pills combined with butylphthalide in treatment of acute cerebral infarction. Methods A total of 146 patients with acute cerebral infarction admitted to Beijing Longfu Hospital from January to December 2022 were selected and divided into control group and treatment group according to random number table method, with 73 patients in each group. Patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection, 100 mL/time, twice daily, infusion time ≥ 50 min/time. Patients in the treatment group were po administered with Naoan Dropping Pills on the basis of the control group, 20 pills/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the scores of the simplified Fugl Meyer Rating Scale (FMA) and the National Institutes of Health Stroke Scale (NIHSS), the parameters of thrombus and platelet, and the levels of serum C-reactive protein (CRP), nitric oxide (NO), superoxide dismutase (SOD), glutamic acid (Glu) were compared between the two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 95.89%, which was significantly higher than that of the control group (86.30%, P < 0.05). After treatment, FMA score in both groups was significantly higher than before treatment, but NIHSS score was significantly lower (P < 0.05). FMA and NIHSS scores in the treatment group were significantly improved (P < 0.05). After treatment, plasma plasminase-anti-plasminase complex (PAP), thrombin antithrombin complex (TAT) and platelet aggregation rate (PAgT) in two groups were significantly decreased compared with before treatment (P < 0.05). The decrease was more significant in the treatment group (P < 0.05). After treatment, serum CRP and Glu levels were significantly decreased, while serum NO and SOD levels were significantly increased in two groups (P < 0.05). The serum levels of CRP, NO, SOD and Glu in the treatment group were significantly improved (P < 0.05). Conclusion Naoan Dropping Pills combined with butylphthalide has good therapeutic effect in treatment of acute cerebral infarction, and can safely and effectively anti-thrombosis, relieve inflammation and oxidative stress damage, promote the improvement of nerve and motor function.

R971

北京市中医药科技发展资金项目（QYSF-2020-06）