瞬时受体电位（TRP）通道是一类主要定位于细胞膜的非特异性阳离子通道，是多种细胞和环境信号的传感器，激活后可与众多生理信号通路相互作用，参与多种生理病理过程。Sigma-1受体是一种特异存在于线粒体相关内质网膜的分子伴侣蛋白，参与调控细胞稳态和细胞应激。TRP通道和Sigma-1受体均广泛存在于哺乳动物体内各组织器官，研究发现二者之间存在相互作用，参与调节不同类型疼痛的发生、发展过程。TRP通道和Sigma-1受体对辣椒素诱导的痛觉过敏、内源性阿片肽镇痛效应、奥沙利铂诱导的周围神经病变、外周免疫驱动的痛觉过敏进行调控。对TRP通道与Sigma-1受体的相互作用及其调控疼痛情况进行了总结。

Transient receptor potential (TRP) channels are a kind of non-specific cation channel mainly residing at plasma membranes, which are sensors for a variety of cellular and environmental signals. Activated TRP channels are involved in various physiological and pathological processes by interacting with many physiological signal pathways. Sigma-1 receptor is a molecular chaperone protein that resides specifically in the mitochondria-associated endoplasmic reticulum membrane, and participated in the modulation of cell homeostasis and cell stress. There is interaction between TRP channels and Sigma-1 receptors, which is involved in regulating the occurrence and development of different types of pain. TRP channels and Sigma-1 receptors regulate capsaicin induced hyperalgesia, endogenous opioid peptide analgesic effects, oxaliplatin induced peripheral neuropathy, and peripheral immune driven hyperalgesia. This article summarizes the interaction between TRP channels and Sigma-1 receptors and their regulation of pain.

R971

甘肃省科技计划项目（20JR10FA663）