目的 探讨胆石利通片联合茴三硫治疗胆石症的临床疗效。方法 选取2020年5月—2023年5月聊城市第二人民医院收治的128例胆石症患者，按随机数字表法分为对照组（64例）和治疗组（64例）。对照组口服茴三硫片，1片/次，3次/d。治疗组在对照组的治疗基础上口服胆石利通片，6片/次，3次/d。两组治疗30 d。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，胆囊壁厚度、胆囊容积、生活质量及血清白细胞介素-6（IL-6）、核转录因子-κB（NF-κB）、肿瘤坏死因子-α（TNF-α）和瘦素（LEP）水平。结果 治疗后，治疗组总有效率为98.44%，明显高于对照组（84.37%，P＜0.05）。治疗后，治疗组恶心呕吐、腹胀、腹泻、右上腹疼痛等缓解时间均明显短于对照组（P＜0.05）。治疗后，两组患者胆囊壁厚度、胆囊容积明显降低，而生活质量评分明显升高（P＜0.05），且治疗组的胆囊壁厚度、胆囊容积均明显低于对照组，生活质量评分明显高于对照组（P＜0.05）。治疗后，两组患者血清炎性因子IL-6、NF-κB、TNF-α、LEP水平明显降低（P＜0.05），且治疗组明显低于对照组（P＜0.05）。结论 茴三硫与胆石利通片协同治疗效果确切，能有效缓解临床症状，改善胆囊功能状态。

Objective To investigate the clinical efficacy of Danshi Litong Tablets combined with anethol trithione in treatment of cholelithiasis. Methods A total of 128 cholelithiasis patients admitted to Liaocheng Second People’s Hospital from May 2020 to May 2023 were selected and divided into control group (64 cases) and treatment group (64 cases) according to random number table method. Patients in the control group were po administered with Anethol Trithione Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Danshi Litong Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 30 d. After treatment, the clinical evaluation was evaluated, the time of symptom relief, the gallbladder wall thickness, gallbladder volume and quality of life, and the serological IL-6, NF-κB, TNF-α and LEP levels in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 98.44%, which was significantly higher than that of the control group (84.37%, P＜0.05). After treatment, the relief time of nausea, vomiting, abdominal distension, diarrhea and right upper abdominal pain in the treatment group was significantly shorter than that in the control group (P＜0.05). After treatment, the gallbladder wall thickness and gallbladder volume in two groups were significantly decreased, while the quality of life score was significantly increased (P＜0.05), and the gallbladder wall thickness and gallbladder volume in the treatment group were significantly lower than those in the control group (P＜0.05), the score of quality of life in the control group was significantly higher than that in the control group (P＜0.05). After treatment, the levels of serum inflammatory factors IL-6, NFκB, TNF-α and LEP in two groups were significantly decreased (P＜0.05), which in the treatment group were significantly lower than those in the control group (P＜0.05). Conclusion The synergistic treatment of anethol trithione and Danshi Litong Tablets has a definite effect, which can effectively alleviate clinical symptoms, improve gallbladder function.

R975

山东中医药科技项目（2021M030）