极光激酶是维持细胞基因组完整性的关键丝氨酸/苏氨酸有丝分裂调节激酶，由3个成员极光激酶A、B、C组成，其中极光激酶B在有丝分裂中起着至关重要的作用。极光激酶B在多种恶性肿瘤中过表达，故极光激酶B被作为有吸引力的抗癌药物靶点被广泛研究，目前已经开发了多种靶向极光激酶B的小分子抑制剂。介绍了极光激酶B特异性抑制剂、进入临床试验阶段的泛极光激酶抑制剂等的研究进展，希望为极光激酶B抑制剂的开发和临床使用提供参考。

Aurora kinase is a key serine/threonine mitotic regulatory kinase that maintains the integrity of the cell genome, consisting of three members, aurora kinases A, B, and C. Aurora kinase B plays a crucial role in mitosis. Over-expression of aurora kinase B is frequently observed in various malignant tumors, so aurora kinase B has been widely studied as an attractive anticancer drug target. Currently, various small molecule inhibitors targeting aurora kinase B have been developed. This article introduces the research progress of aurora kinase B specific inhibitors and pan-aurora kinase inhibitors entering the clinical trial stage, hoping to provide reference for the development and clinical use of aurora kinase B inhibitors.

R961

甘肃省自然科学基金资助项目(22JR5RA021)