目的 探讨复方甘菊利多卡因凝胶联合聚维酮碘含漱液治疗牙周炎的临床疗效。方法 选择2022年2月—2023年2月在秦皇岛市海港医院治疗的66例牙周炎患者为研究对象，依据用药方案的差别分为对照组（33例）和治疗组（33例）。对照组含漱聚维酮碘含漱液，10 mL/次，每次10秒，4次/d；在此基础上，治疗组给予复方甘菊利多卡因凝胶，每次涂0.5 cm凝胶于牙龈处并稍加按摩，3次/d。两组患者均经2周治疗。观察两组患者临床疗效，比较治疗前后两组患者症状改善时间，GSES评分、OHIP-14评分和VAS评分，牙周指标探诊深度（PD）、龈沟出血指数（SBI）、临床附着水平（CAL）和菌斑指数（PLI）水平，及血清学指标C反应蛋白（CRP）、白细胞介素-1β（IL-1β）、白细胞介素-17（IL-17）、高迁移率族蛋白B1（HMGB1）、白细胞介素-6（IL-6）和降钙素基因相关肽（CGRP）水平。结果 治疗后，治疗组临床有效率（96.97%）明显高于对照组（75.76%，P＜0.05）。治疗后，治疗组症状改善时间均明显早于对照组（P＜0.05）。治疗后，两组GSES评分明显升高，而OHIP-14评分和VAS评分均明显降低（P＜0.05），并以治疗组量表评分改善最为显著（P＜0.05）。治疗后，两组患者PD、SBI、CAL、PLI、CRP、IL-1β、IL-17、HMGB1和IL-6水平均明显下降，而CGRP水平明显升高（P＜0.05），且治疗组患者上述指标改善最显著（P＜0.05）。结论 复方甘菊利多卡因凝胶联合聚维酮碘含漱液治疗牙周炎可有效改善临床症状，降低机体炎症反应，促进患者口腔健康与自我效能感。

Objective To investigate the clinical efficacy of Compound Chamomile and Lidocaine Hydrochloride Gel combined with Povidone-iodine Gargle and Mouthwash in treatment of periodontitis. Methods Patients (66 cases) with periodontitis in Qinhuangdao Haigang Hospital from February 2022 to February 2023 were divided into control (33 cases) and treatment (33 cases) group based on different treatments. Patients in the control group were administered with Povidone-iodine Gargle and Mouthwash, 10 mL/time, 10 s/time, four times daily. Patients in the treatment group were administered with Compound Chamomile and Lidocaine Hydrochloride Gel on the basis of the control group, 0.5 cm gel Applied to the gums each time and massage slightly, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical evaluation was evaluated, and the improvement time of symptom, the scores GSES, OHIP-14 and VAS, the levels of periodontal indicators PD, SBI, CAL and PLI, the levels of serological indexes CRP, IL-1β, IL-17, HMGB1, IL-6 and CGRP in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (96.97%) was significantly higher than that of the control group (75.76%, P < 0.05). After treatment, the improvement time of symptom in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the GSES score was significantly increased, while the OHIP-14 score and VAS score were significantly decreased in two groups (P < 0.05), and the score of the treatment group was improved most significantly (P < 0.05). After treatment, the levels of PD, SBI, CAL, PLI, CRP, IL-1β, IL-17, HMGB-1 and IL-6 were significantly decreased, while the level of CGRP was significantly increased in two groups (P < 0.05), and the above-mentioned indexes were improved most significantly in the treatment group (P < 0.05). Conclusion Compound Chamomile and Lidocaine Hydrochloride Gel combined with Povidone-iodine Gargle and Mouthwash in treatment of periodontitis can effectively improve clinical symptoms, reduce inflammatory reaction, and promote patients’ oral health and self-efficacy.

R988.2

河北省医学科学研究课题计划项目(20201321);秦皇岛市科学技术课题项目(201902A187)