目的 探讨补血益母颗粒联合麦角新碱治疗宫缩乏力性产后出血的临床疗效。方法 选取2021年3月-2023年3月海口市妇幼保健院收治的80例宫缩乏力性出血患者，随机法分为对照组（40例）和治疗组（40例）。对照组肌肉注射马来酸麦角新碱注射液，0.2 mg/次，每日次数不超过5次。在对照组的基础上，治疗组口服补血益母颗粒，12 g/次，3次/d。两组均完成5 d治疗。观察两组患者临床疗效，比较治疗前后两组患者活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、凝血酶原时间（PT）和纤维蛋白原（FIB）指标水平，产后出血量和止血时间，及子宫体积和宫底下降高度。结果 治疗后，治疗组临床有效率（97.50%）明显高于对照组（85.00%，P<0.05）。治疗后，两组患者TT、PT、APTT指标均低于治疗前，而FIB指标高于治疗前（P<0.05），且治疗组凝血功能指标明显好于对照组（P<0.05）。治疗后，治疗组患者止血时间显著短于对照组（P<0.05），治疗组30 min及2、24 h的出血量均逐渐低于对照组（P<0.05）。治疗后，两组患者子宫体积、宫底下降高度指标均低于治疗前（P<0.05），且治疗组明显低于对照组（P<0.05）。结论 补血益母颗粒联合麦角新碱治疗宫缩乏力性产后出血效果确切，可有效纠正机体凝血状态，增强子宫收缩力，并同时缩短产后出血量，且安全有效。

Objective To explore the effects of Buxue Yimu Granules combined with ergometrine in treatment of postpartum hemorrhage caused by uterine atony. Methods Patients (80 cases) with rheumatoid arthritis in Haikou Hospital of the Maternal and Child Health from March 2021 to March 2023 were randomly divided into control (40 cases) and treatment (40 cases) group. Patients in the control group were intramuscular injection administered with Ergometrine Maleate Injection, 0.2 mg/time, no more than 5 times per day. Patients in the treatment group were po administered with Buxue Yimu Granules on the basis of the control group, 12 g/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, and the indicators of TT, PT, APTT, FIB, bleeding volume, hemostasis, uterine volume and fundus descent in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (97.50%) was significantly higher than that of the control group (85.00%, P < 0.05). After treatment, the indexes of TT, PT and APTT in two groups were lower than those before treatment, while the index of FIB was higher (P < 0.05), and the indexes of blood coagulation in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the hemostatic time of the treatment group was significantly shorter than that of the control group (P < 0.05), and the bleeding volume of 30 min, 2 h and 24 h in the treatment group was gradually lower than that in the control group (P < 0.05). After treatment, the uterine volume and uterine floor descending height in both groups were lower than those before treatment (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Buxue Yimu Granules combined with ergometrine in treatment of postpartum hemorrhage caused by uterine atony is effective, which can enhance uterine contractility and shorten the amount of postpartum hemorrhage. It is safe and effective.

R984

海南省自然科学基金青年项目（821QN395）