目的 探讨便通片联合双歧杆菌乳杆菌三联活菌片治疗慢性功能性便秘的临床疗效。方法 选取2021年1月-2022年12月明光市人民医院收治的78例慢性功能性便秘患者，随机分为对照组（39例）和治疗组（39例）；对照组患者口服双歧杆菌乳杆菌三联活菌片，4片/次，3次/d。在对照组的基础上，治疗组口服便通片，3片/次，2次/d；两组治疗5 d。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，生活质量评分，及C反应蛋白（CRP）和胃泌素（GAS）水平。结果 治疗后，治疗组患者临床有效率为97.44%，明显高于对照组（76.92%，P<0.05）。治疗后，治疗组症状缓解时间均明显早于对照组（P<0.05）。治疗后，两组患者慢性便秘生活质量自评（PAC-QOL）量表各项目评分均明显降低（P<0.05），且治疗组明显低于对照组（P<0.05）。治疗后，两组患者CRP水平均低于治疗前，而GAS水平均高于治疗前（P<0.05），且治疗组患者CRP和GAS水平明显好于对照组（P<0.05）。结论 便通片联合双歧杆菌乳杆菌三联活菌片治疗慢性功能性便秘效果确切，可有效缓解便秘症状，能促使胃肠功能改善明显，并有效减弱炎性反应，患者生活质量改善显著。

Objective To investigate the clinical efficacy of Biantong Tablets combined with Live Combined Bifidobacterium and Lactobacillus Tablets in treatment of chronic functional constipation. Methods Patients (78 cases) with chronic functional constipation in Mingguang People's Hospital from January 2021 to December 2022 were randomly divided into control (39 cases) and treatment (39 cases) group. Patients in the control group were po administered with Live Combined Bifidobacterium and Lactobacillus Tablets, 4 tablets/time, three times daily. Patients in the treatment group were po administered with Biantong Tablets on the basis of the control group, 3 tablets/time, twice daily. Patients in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, and the relief time of symptom, PAC-QOL scores, the levels of CRP and GAS in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.44%, which was significantly higher than that of the control group (76.92%, P< 0.05). After treatment, the time of symptom relief in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the scores of PAC-QOL in two groups were significantly decreased (P < 0.05), and the scores in the treatment group were significantly lower than that in the control group (P < 0.05). After treatment, the levels of CRP in two groups were lower than those before treatment, while the levels of GAS were higher (P < 0.05), and the levels of CRP and GAS in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Biantong Tablets combined with Live Combined Bifidobacterium and Lactobacillus Tablets in treatment of chronic functional constipation is effective, which can effectively relieve the symptoms of constipation, improve gastrointestinal function significantly, and effectively weaken the inflammatory reaction, and the quality of life of patients is significantly improved.

R975