目的 探讨地衣芽孢杆菌活菌颗粒联合头孢克洛治疗小儿急性细菌性肠炎的临床疗效。方法 选择2022年1月-2022年11月在南通市海门区人民医院治疗的细菌性肠炎患儿80例,随机分为对照组(40例)和治疗组(40例)。对照组口服头孢克洛干混悬剂,0.125 g/次,3次/d。在对照组治疗基础上,治疗组口服地衣芽孢杆菌活菌颗粒,0.5袋/次,3次/d。两组患儿治疗5 d。观察两组患儿临床疗效,比较治疗前后两组患儿症状好转时间,外周血白细胞(WBC)、中性粒细胞(NE)水平,血清炎性因子降钙素原(PCT)、血清淀粉样蛋白(SAA)、肌酸激酶同工酶(CK-MB)、C反应蛋白(CRP)水平,及不良反应情况。结果 治疗后,治疗组临床有效率(97.51%)明显高于对照组有效率(82.50%,P<0.05)。治疗后,治疗组症状好转时间均早于对照组(P<0.05)。治疗后,两组患儿外周血WBC、NE、CK-MB、SAA、PCT、CRP水平均明显降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,治疗组不良反应发生率为7.51%,明显低于对照组(17.50%,P<0.05)。结论 地衣芽孢杆菌活菌颗粒联合头孢克洛治疗小儿急性细菌性肠炎效果确切,显著改善细菌肠炎引起的发热、大便次数多等症状,各炎症反应显著降低。

Objective To explore the clinical study of Bacillus Licheniformis Granules, Live combined with cefaclor in treatment of acute bacterial enteritis in children. Methods Children (80 cases) with acute bacterial enteritis in children in Nantong Haimen People's Hospital from January 2022 to November 2022 were randomly divided into control (40 cases) and treatment (40 cases) group. Children in the control group were po administered with Cefaclor for Suspension, 0.125 g/time, three times daily. Children in the treatment group were po administered with Bacillus Licheniformis Granules, Live on the basis of the control group, 1/2 bag/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, and the improvement time of symptoms, WBC and NE levels in peripheral blood, the levels of CK-MB, SAA, PCT and CRP, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (97.51%) was significantly higher than that of the control group (82.5%, P < 0.05). After treatment, the time of improvement of symptoms in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the levels of WBC, NE, CK-MB, SAA, PCT and CRP in peripheral blood in two groups were significantly decreased (P < 0.05), and the levels of these indexes in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the treatment group was 7.51%, which was significantly lower than that in the control group (17.50%, P < 0.05). Conclusion Bacillus Licheniformis Granules, Live combined with cefaclor in treatment of acute bacterial enteritis in children is effective, and can iimprove fever and fecal frequency caused by bacterial enteritis, and the inflammatory reaction is significantly reduced.

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