目的 探讨槐杞黄颗粒联合复方倍他米松注射液治疗白癜风的临床疗效。方法 选取2021年5月—2022年10月在黑龙江省医院南岗院区就诊的白癜风患者70例，随机分为对照组和治疗组，每组各35例。对照组患者im复方倍他米松注射液，1 mL/次，每月1次，共3次；同时给予CO₂点阵激光治疗，之后用复方倍他米松注射液外敷治疗处，每月1次，共3次。治疗组在对照组治疗基础上口服槐杞黄颗粒，2袋/次，2次/d。两组患者均治疗3个月。观察两组患者临床疗效，比较治疗前后两组患者T细胞亚群变化和白斑面积和复色率。结果 治疗后，治疗组患者总有效率为91.43%，显著高于对照组的65.71%（P＜0.05）。治疗后，两组CD8^＋ T细胞占比显著低于治疗前，而两组CD3^＋和CD4^＋ T细胞占比显著升高，CD4^＋/CD8^＋ T细胞值也均显著增高（P＜0.05）；且治疗组T细胞亚群变化明显好于对照组（P＜0.05）。治疗后，两组皮损均明显缩小（P＜0.05），治疗组白斑面积小于对照组（P＜0.05），治疗组的复色率明显高于对照组（P＜0.05）。结论 槐杞黄颗粒联合复方倍他米松注射液治疗白癜风疗效显著，可调节机体免疫功能，缩小白斑面积，提高复色率。

Objective To observe the clinical efficacy of Huaiqihuang Granules combined with compound betamethasone in treatment of vitiligo. Methods Patients (70 cases) with vitiligo in Nangang District of Heilongjiang Provincial Hospital from May 2021 to October 2022 were randomly divided into control and treatment group, and each group had 35 cases. Patients in the control group were intramuscular injection administered with Compound Betamethasone Injection, 1 mL/time, once monthly for 3 months. They were given CO₂ lattice laser treatment, followed by external application of Compound Betamethasone Injection, once monthly for 3 months. Patients in the treatment group were po administered with Huaiqihuang Granules on the basis of the control group, 2 bags/time, twice daily. Patients in two groups were treated for 3 months. After treatment, the clinical evaluation was evaluated, and the changes of T cell subsets and white spot area and re pigmentation rate in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 91.43%, which was significantly higher than that of the control group (65.71%, P < 0.05). After treatment, the proportion of CD8⁺ T cells in two groups was significantly lower than that before treatment, while the proportion of CD3⁺ and CD4⁺ T cells and the ratio of CD4⁺/CD8⁺ T cells in two groups were significantly increased (P < 0.05), and the change of T cell subsets in the treatment group was significantly better than that in the control group (P < 0.05). After treatment, the skin lesions in two groups were significantly reduced (P < 0.05), the leukoplakia area of the treatment group was lower than that of the control group (P < 0.05), and the color recovery rate of the treatment group was significantly higher than that of the control group (P < 0.05). Conclusion Huaiqihuang Granules combined with Compound Betamethasone Injection is effective in treatment of vitiligo, which can regulate the immune function of the body, reduce the area of leukoplakia and improve the recovery rate.

R986

湖北陈孝平科技发展基金会2021年度免疫性疾病研究槐杞黄专项基金资助项目（CXPJJH121002-202126）