目的 探讨正柴胡饮颗粒联合复方氨酚烷胺胶囊治疗流行性感冒的临床疗效。方法 选取2020年11月—2022年12月河南中医药大学第三附属医院收治的122例感冒患者，随机分为对照组和治疗组，每组各61例。对照组口服复方氨酚烷胺胶囊，1粒/次，2次/d。在对照组的基础上，治疗组口服正柴胡饮颗粒，3 g/次，3次/d。两组患者治疗5 d。观察两组患者临床疗效，比较治疗前后两组患者症状好转时间，血清因子C反应蛋白（CRP）、降钙素原（PCT）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）水平，及不良反应情况。结果 治疗后，治疗组患者临床有效率（98.36%）明显高于对照组（85.26%，P＜0.05）。治疗后，治疗组症状好转时间均早于对照组（P＜0.05）。治疗后，两组患者血清因子IL-6、PCT、TNF-α、CRP水平均明显低于治疗前（P＜0.05），且治疗组患者血清因子水平均明显低于对照组（P＜0.05）。治疗后，治疗组不良反应发生率为6.57%，明显低于对照组发生率（11.48%，P＜0.05）。结论 复方氨酚烷胺胶囊联合正柴胡饮颗粒治疗流行性感冒效果确切，较快缓解感冒症状，并能有效降低机体炎性反应。

Objective To explore the therapeutic effect of Zhengchai Huyin Granules combined with Compound Paracetamol and Amantadine Hydrochloride Capsules in treatment of influenza. Methods Patients (122 cases) with influenza in the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from November 2020 to December 2022 were randomly divided into control and treatment group, and each group had 61 cases. Patients in the control group were po administered with Compound Paracetamol and Amantadine Hydrochloride Capsules, 1 grain/time, twice daily. Patients in the treatment group were po administered with Zhengchai Huyin Granules on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, and the improvement time of symptom, the serum factors IL-6, PCT, TNF-α and CRP levels, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (98.36%) was significantly higher than that of the control group (85.26%, P < 0.05). After treatment, the improvement time of symptom in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the serum levels of IL-6, PCT, TNF-α and CRP in two groups were significantly lower than those before treatment, and the levels of serum factors in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the treatment group was 6.57%, which was significantly lower than that in the control group (11.48%, P < 0.05). Conclusion Compound Paracetamol and Amantadine Hydrochloride Capsules combined with Zhengchai Huyin Granules in treatment of influenza is effective in relieving cold symptoms and effectively reducing inflammatory reaction.

R974