松果体被认为是昼夜节律的神经内分泌转换器,以高度昼夜节律的方式产生褪黑素,发挥其抗氧化、抗肿瘤、延缓衰老等生物学功能,传播昼夜节律的信息。当松果体受损后,褪黑素分泌量下降,会引起患者神经过度兴奋、免疫力降低、抗氧化能力降低等一系列表现。专门制备松果体损伤的动物模型的研究报道很少,化学性因素、物理性因素和综合因素均可致大鼠松果体损伤,可用于制备松果体损伤的动物模型。因此总结了松果体损伤动物模型的制备方法,为建立方法简便、成模时间短的松果体损伤模型提供依据。

Pineal is considered as the neuroendocrine converter of circadian rhythm. It produces melatonin in a highly circadian rhythm way, exerts its biological functions, such as anti-oxidation, anti-tumor, and anti-aging, and spreads the information of Circadian rhythm.When pineal is damaged, the secretion of melatonin decreases, which will cause a series of symptoms such as overexcitation of nerves,decreased immunity, and reduced antioxidant capacity. There are few studies on the specific preparation of pineal damage model.Chemical factors, physical factors, and comprehensive factors can cause damage to pineal of rats, which can be used to prepare animal models of pineal damage. In this paper, the preparation methods of animal models of pineal injury were summarized, which provided a basis for the establishment of a simple and rapid pineal injury model.

R965.1

山西省自然科学基金面上项目(201901D111427);山西省卫生健康委员会“四个一批”科技兴医创新计划项目(2020SYS06)