目的 探讨龙血竭片联合塞来昔布胶囊治疗血瘀型腰椎间盘突出症的临床疗效。方法 选取2022年1月—2022年6月天津市北辰医院收治的100例血瘀型腰椎间盘突出症患者,随机分为对照组和治疗组,每组各50例。对照组患者口服塞来昔布胶囊,0.2 g/次,1次/d。治疗组患者在对照组基础上口服龙血竭片,6片/次,3次/d。两组患者均治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者视觉模拟评分法(VAS)、日本骨科协会评估治疗分数(JOA)和Oswestry功能障碍指数(ODI)评分,及超氧化物歧化酶(SOD)、丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)和白细胞介素-6(IL-6)水平。结果 治疗后,治疗组总有效率显著高于对照组(96.00%vs 84.00%,P<0.05)。治疗后,两组患者VAS和ODI评分显著低于治疗前,而JOA评分显著高于治疗前(P<0.05);且治疗组各项评分显著好于对照组(P<0.05)。治疗后,两组患者MDA水平显著降低,而SOD水平显著升高(P<0.05),且治疗组患者氧化应激水平显著好于对照组(P<0.05)。治疗后,两组患者TNF-α、IL-1和IL-6水平显著低于治疗前(P<0.05),且治疗组患者炎症因子水平显著低于对照组(P<0.05)。结论 龙血竭片联合塞来昔布胶囊治疗腰椎间盘突出症的疗效和安全性均较高,能有效减轻氧化应激和炎性反应,缓解腰腿疼痛以及改善腰椎功能。

Objective To investigate the effect of Longxuejie Tablets and celecoxib in treatment of lumbar disc herniation.Methods Patients(100 cases) with lumbar disc herniation in Tianjin Beichen Hospital from January 2022 to June 2022 were randomly divided into control and treatment group, and each group had 50 cases. Patients in the control group were po administered with Celecoxib Capsules,0.2 g/time, once daily. Patients in the treatment group were po administered with Longxuejie Tablets on the basis of the control group,6 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated,and the scores of VAS, ODI and JOA, and the levels of MDA, SOD, TNF-α, IL-1 and IL-6 in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group(96.00% vs 84.00%, P<0.05). After treatment, the scores of VAS and ODI in two groups were significantly lower than those before treatment, while the score of JOA was significantly higher, and the scores in the treatment group were significantly better than those in the control group(P<0.05). After treatment, the level of MDA in two groups was significantly decreased, while the level of SOD was significantly increased, and the level of oxidative stress in the treatment group was significantly better than that in the control group(P<0.05). After treatment, the levels of TNF-α, IL-1 and IL-6 in two groups were significantly lower than those before treatment, and which in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Longxuejie Tablets combined with Celecoxib Capsules has high efficacy and safety in the treatment of lumbar disc herniation, which can effectively reduce oxidative stress and inflammatory reaction, relieve waist and leg pain and improve lumbar function.

R977