目的 探讨强骨胶囊联合依托考昔片治疗膝骨性关节炎的临床疗效。方法 选取2021年3月—2022年12月安阳市人民医院收治的88例膝骨性关节炎患者作为研究对象,根据随机数字表法将所有患者分为对照组和治疗组,每组各44例。对照组口服依托考昔片,1片/次,1次/d。治疗组在对照组基础上口服强骨胶囊,1粒/次,3次/d。两组患者连续治疗1个月。观察两组的临床疗效,比较两组患者膝关节活动度、主观疼痛程度、病情程度和关节液炎性因子水平。结果 治疗后,治疗组的总有效率为95.45%,高于对照组的总有效率79.55%,组间比较差异有统计学意义(P<0.05)。治疗后,两组的屈曲角度、过伸角度明显高于治疗前(P<0.05);治疗后,治疗组的屈曲角度、过伸角度明显高于对照组(P<0.05)。治疗后,两组的视觉模拟评分法(VAS)、骨性关节炎评估量表(WOMAC)评分均明显低于治疗前(P<0.05),且治疗组VAS、WOMAC评分均明显低于对照组(P<0.05)。治疗后,两组关节液中基质金属蛋白酶-13(MMP-13)、金属蛋白酶组织抑制因子-1(TIMP-1)、肿瘤坏死因子-α(TNF-α)水平均显著低于治疗前(P<0.05),且治疗组的关节液中MMP-13、TIMP-1、TNF-α水平明显低于对照组(P<0.05)。结论 强骨胶囊联合依托考昔片治疗膝骨性关节炎疗效确切,能提高膝关节活动度,减轻疼痛和病情,降低炎症损伤,且安全性良好。

Objective To investigate the clinical effect of Qianggu Capsules combined with Etocoxi Tablets in treatment of knee osteoarthritis.Methods Patients(88 cases) with knee osteoarthritis in the People's Hospital of Anyang City from March 2021 to December 2022 were divided into control and treatment groups according to the random number table method, and each group had 44cases. Patients in the control group were po administered with Etocoxi Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Qianggu Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the knee joint range of motion, subjective pain level, severity of illness, and levels of inflammatory factors in joint fluid in two groups were compared.Results After treatment, the total effective rate of the treatment group was 95.45%, which was higher than that of the control group(79.55%), and the difference between groups was statistically significant(P<0.05). After treatment, the flexion angle and hyperextension angle of two groups were significantly higher than before treatment(P<0.05). After treatment, the flexion angle and hyperextension angle in the treatment group were significantly higher than those in the control group(P<0.05). After treatment, the VAS scores and WOMAC scores of two groups were significantly lower than before treatment(P<0.05), and the VAS scores and WOMAC scores of the treatment group were significantly lower than those of the control group(P<0.05). After treatment, the levels of MMP-13, TIMP-1, and TNF-α in joint fluid of two groups were significantly lower than before treatment(P<0.05), and the levels of MMP-13, TIMP-1, and TNF-α in joint fluid of two groups were significantly lower than those of control group(P<0.05).Conclusion Qianggu Capsules combined with Etocoxi Tablets has definite efficacy in treatment of knee osteoarthritis, which can reduce pain and disease, improve knee motion,reduce inflammation and injury, and has good safety.

R977

河南省中医药科学研究专项课题(20-21ZY2024)