目的 观察丹参酮胶囊联合地奈德乳膏治疗头面部脂溢性皮炎的临床疗效。方法 选取2021年1月—2022年7月在芜湖市中医医院就诊的136例头面部脂溢性皮炎患者,随机分为对照组和治疗组,每组各68例。对照组患者清洁头面部,外涂适量地奈德乳膏,2次/d。治疗组在对照组的基础上口服丹参酮胶囊,4粒/次,3次/d。两组患者连续治疗2周。观察两组患者临床疗效,比较治疗前后两组患者症状体征评分,血清炎性指标及血清过氧化氢酶(CAT)和超氧化物歧化酶(SOD)水平。结果 治疗后,治疗组的总有效率显著高于对照组(91.18%vs 76.47%,P<0.05)。治疗后,两组症状体征评分及总评分比治疗前显著下降(P<0.05),且治疗组皮损面积等症状体征评分及总评分显著低于对照组(P<0.05)。治疗后,两组患者血清白细胞介素-2(IL-2)、IL-10水平明显升高,而IL-4、γ干扰素(IFN-γ)显著降低(P<0.05);且治疗后,治疗组IL-2、IL-10水平明显高于对照组,而IL-4、IFN-γ水平显著低于对照组(P<0.05)。治疗后,两组血清CAT、SOD水平较治疗前明显升高(P<0.05),且治疗组显著高于对照组(P<0.05)。结论 丹参酮胶囊联合地奈德乳膏治疗头面部脂溢性皮炎的疗效明显,可有效改善患者的症状体征,能改善血清炎性指标和氧化应激状态。

Objective To observe the efficacy of Danshentong Capsules combined with desonide cream in treatment of seborrheic dermatitis of head and face.Methods Patients(136 cases) with seborrheic dermatitis of head and face in Wuhu Hospital of Traditional Chinese Medicine from January 2021 to July 2022 were randomly divided into control and treatment group, and each group had 68 cases.Patients in the control group cleaned their faces and applied appropriate amount of desonide cream, twice daily. Patients in the treatment group were po administered with Danshentong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical evaluation was evaluated, and symptom and sign scores, serum inflammatory indexes, serum catalase(CAT) and superoxide dismutase(SOD) levels were compared between the two groups before and after treatment.Results After treatment, the total effective rate of the treatment group was significantly higher than that of the control group(91.18% vs 76.47%, P<0.05). After treatment, the scores of symptoms and signs and the total score in two groups were significantly lower than those before treatment(P<0.05), and which in the treatment group were significantly lower than those in the control group(P<0.05). After treatment, the serum levels of IL-2 and IL-10 in two groups were significantly increased, but IL-4 and IFN-γ were significantly decreased(P<0.05). After treatment, the levels of IL-2 and IL-10 in the treatment group were significantly higher than those in the control group,but the levels of IL-4 and IFN-γ were significantly lower than those in the control group(P<0.05). After treatment, the levels of serum CAT and SOD in two groups were significantly higher than those before treatment(P<0.05), and which in the treatment group were significantly higher than those in the control group(P<0.05).Conclusion Danshentong Capsules combined with desonide cream is effective in treatment of head and face seborrheic dermatitis, can effectively improve the symptoms and signs, and can improve serum inflammatory indexes and oxidative stress state.

R986