目的 探讨芩翘口服液联合头孢克肟治疗小儿急性扁桃体炎的临床疗效。方法 选取2019年6月—2022年6月东营市东营区人民医院收治的96例急性扁桃体炎患儿,按随机数字表法将所有患者分为对照组和治疗组,每组各48例。对照组口服头孢克肟颗粒,体质量<30 kg者,每次3 mg/kg,2次/d;体质量≥30 kg者,100 mg/次,2次/d。治疗组在对照组基础上口服芩翘口服液,1~4岁者,5 mL/次,3次/d;5~7岁者,8 mL/次,3次/d;8~12岁者,10 mL/次,3次/d。两组疗程均为5 d。观察两组临床疗效,比较治疗前后两组典型症状积分、儿童睡眠习惯问卷(CSHQ)总分、儿童生活质量普适性核心量表4.0(PedsQL4.0)总分及血清C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)和降钙素原(PCT)水平。统计两组不良反应情况。结果 治疗后,治疗组总有效率为97.92%,显著高于对照组的87.50%(P<0.05)。治疗后,两组咽痛积分、咽干灼热积分、发热积分、扁桃体肿大积分、喉核黏膜充血积分均显著降低(P<0.05),均以治疗组下降更显著(P<0.05)。治疗后,两组CSHQ总分均显著降低,而PedsQL4.0总分均显著增加(P<0.05),均以治疗组改善更显著(P<0.05)。治疗后,两组血清CRP、SAA、PCT水平均显著下降(P<0.05),均以治疗组降低更显著(P<0.05)。治疗过程中,治疗组和对照组不良反应发生率分别是6.25%、4.17%,两组不良反应发生率比较差异无统计学意义。结论 芩翘口服液联合头孢克肟治疗小儿急性扁桃体炎可获得满意疗效,能安全有效地缓解患儿临床症状,促进睡眠质量与生活质量的改善,显著降低机体感染程度,减轻炎性损伤。

Objective To investigate the clinical effect of Qinqiao Oral Liquid combined with cefixime in treatment of acute tonsillitis in children.Methods A total of 96 children with acute tonsillitis admitted to Dongying District People's Hospital of Dongying City from June 2019 to June 2022 were selected and divided into control group and treatment group according to random number table method, with 48 cases in each group. Patients in the control group were po administered with Cefixime Granules, body weight < 30kg, 3 mg/kg each time, twice daily, body weight ≥ 30 kg, 100 mg/time, twice daily. Patients in the treatment group were po administered with Qinqiao Oral Liquid on the basis of the control group, 1 — 4 years old, 5 mL/time, 3 times daily, 5 — 7 years old, 8 mL/time, 3times daily, 8 — 12 years old, 10 mL/time, 3 times daily. The treatment course of both groups was 5 d. The clinical efficacy of the two groups was observed, and the typical symptom scores, the total score of children's Sleep Habits Questionnaire(CSHQ), the total score of children's Quality of Life Universal Core Scale 4.0(PedsQL4.0), the serum C-reactive protein(CRP), serum amyloid protein A(SAA), and procalcitonin(PCT) levels of the two groups were compared before and after treatment. The adverse reactions of the two groups were analyzed.Results After treatment, the total effective rate of the treatment group was 97.92%, which was significantly higher than that of the control group(87.50%, P<0.05). After treatment, pharyngeal pain score, pharyngeal dry burning score, fever score, tonsil enlargement score and throat nucleus mucosal congestion score were significantly decreased in two groups(P<0.05), and they were more significantly decreased in the treatment group(P<0.05). After treatment, the total score of CSHQ was significantly decreased in both groups, while the total score of PedsQL4.0 was significantly increased(P<0.05), and the improvement was more significant in the treatment group(P<0.05). After treatment, serum CRP, SAA and PCT levels in two groups were significantly decreased(P<0.05), and they were more significantly decreased in the treatment group(P<0.05). During the treatment, the incidence of adverse reactions in the treatment group and the control group was 6.25% and 4.17%, respectively, and there was no statistical significance in the incidence of adverse reactions between the two groups.Conclusion Qinqiao Oral Liquid combined with cefixime has satisfactory efficacy in treatment of acute tonsillitis in children, and can safely and effectively relieve the clinical symptoms of children, promote the improvement of sleep quality and quality of life, and can significantly reduce the degree of body infection, which can reduce inflammatory injury.

R985; R987

山东省医药卫生科技发展计划项目(2019WS042)