目的 探讨脑立清丸联合缬沙坦氨氯地平治疗原发性高血压的临床疗效。方法 选取2020年8月—2022年8月在河南中医药大学第三附属医院诊治的116例高血压患者,按照随机数字表法将患者分为对照组(58例)和治疗组(58例)。对照组患者口服缬沙坦氨氯地平片(Ⅰ),1片/次,1次/d。治疗组在对照组的基础上口服脑立清水丸,10丸/次,2次/d。两组患者均治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者症状缓解时间,收缩压(SBP)和舒张压(DBP)水平,氧化应激指标丙二醛(MDA)、内皮素-1(ET-1)、一氧化氮(NO)和超氧化物歧化酶(SOD)水平及不良反应情况。结果 治疗后,治疗组总有效率(98.28%)显著高于对照组(84.48%,P<0.05)。治疗后,治疗组患者头晕、心悸、头痛、气短缓解时间均短于对照组(P<0.05)。治疗后,两组患者SBP、DBP水平比治疗前明显下降(P<0.05),且治疗组患者血压水平明显优于对照组(P<0.05)。治疗后,两组患者MDA、ET-1明显降低,而SOD和NO水平明显升高(P<0.05),且治疗组氧化应激水平明显好于对照组(P<0.05)。治疗后,治疗组不良反应发生率(6.89%)明显低于对照组(15.52%,P<0.05)。结论 脑立清丸联合缬沙坦氨氯地平治疗效果确切,可缓解症状,能有效减低患者高血压,改善机体氧化应激反应状态。

Objective To investigate the efficacy of Naoliqing Pills combined with valsartan amlodipine in treatment of primary hypertension.Methods Patients(116 cases) with primary hypertension in the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from August 2020 to August 2022 were divided into control group(58 cases) and treatment group(58cases) according to random number table method. Patients in the control group were po administered with Valsartan and Amlodipine Tablets(Ⅰ), 1 tablet/time, once daily. Patients in the treatment group were po administered with Naoliqing Pills on the basis of the control group, 10 pills/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated,and the symptom relief time, the level of SBP and DBP, the levels of MDA, SOD, ET-1 and NO, and adverse reaction in two groups before and after treatment were compared.Results After treatment, the total effective rate of the treatment group(98.28%) was significantly higher than that of the control group(84.48%, P<0.05). After treatment, the relief time of dizziness, palpitation, headache and shortness of breath in the treatment group was shorter than that in the control group(P<0.05). After treatment, the levels of SBP and DBP in the two groups were significantly lower than those before treatment(P<0.05), and the blood pressure in the treatment group was significantly better than that in the control group(P<0.05). After treatment, the levels of MDA and ET-1 were significantly decreased, while the levels of SOD and NO were significantly increased in two groups(P<0.05), and the level of oxidative stress in the treatment group was significantly better than that in the control group(P<0.05). After treatment, the incidence of adverse reactions in the treatment group(6.89%) was significantly lower than that in the control group(15.52%, P<0.05).Conclusion Naoliqing Pills combined with valsartan amlodipine is effective in the treatment of symptoms, which can effectively reduce hypertension and improve the state of oxidative stress in patients.

R972