三七皂苷R₁为三七中特有成分，药理作用广泛。三七皂苷R₁通过抗炎、抗凋亡、改善能量代谢、抑制氧化应激、抑制心肌纤维化、抗心律失常、舒张血管和促血管生成等作用有效防治多种心血管疾病，如缺血性心脏病、动脉粥样硬化、高血压、心肌炎、心律失常、心肌肥厚和心力衰竭等。针对三七皂苷R₁在心血管疾病防治方面的分子机制研究进行综述，以期为进一步开发三七皂苷R₁的潜在治疗价值和临床应用发挥参考作用。

Notoginsenoside R₁ is a unique component in Panax notoginseng, with extensive pharmacological effects. Notoginsenoside R₁ can effectively prevent and treat a variety of cardiovascular diseases, such as ischemic heart disease, atherosclerosis, hypertension, myocarditis, arrhythmia, myocardial hypertrophy and heart failure, through anti-inflammatory, anti-apoptosis, improving energy metabolism, inhibiting oxidative stress, inhibiting myocardial fibrosis, anti-arrhythmia, vasodilation and promoting angiogenesis. This article reviews the research on the molecular mechanism of notoginsenoside R₁ in prevention and treatment of cardiovascular diseases, hoping to play a reference role in further developing the potential therapeutic value and clinical application of notoginsenoside R₁.

R972

湖北省教育厅科学研究计划项目（B2022115）；湖北中医药大学青苗计划项目（2021ZZX027）