目的 探讨妇炎康软胶囊联合头孢地尼胶囊治疗慢性盆腔炎的临床疗效。方法 选取2020年8月—2022年6月平顶山市妇幼保健院收治的104例慢性盆腔炎患者，根据随机数字表法将所有患者分对照组和治疗组，每组各52例。对照组患者口服头孢地尼胶囊，1粒/次，3次/d。治疗组在对照组治疗基础口服妇炎康软胶囊，6粒/次，3次/d。两组患者连续治疗14 d。观察两组的临床疗效，比较症状消失时间、盆腔积液、炎性包块最大直径的变化以及血清中粒细胞-巨噬细胞集落刺激因子（GM-CSF）、白细胞介素-8（IL-8）、白细胞介素-2（IL-2）水平。结果 治疗后，治疗组的总有效率为96.15%，对照组的总有效率为82.69%，两组组间比较差异有显著性（P＜0.05）。治疗后，治疗组患者发热、腹痛、白带异常消失时间短于对照组（P＜0.05）。治疗后，两组的盆腔积液、炎性包块最大直径显著低于治疗前（P＜0.05），且治疗组盆腔积液、炎性包块最大直径较对照组更低（P＜0.05）。治疗后，两组的血清GM-CSF、IL-8水平显著低于治疗前，血清IL-2水平高于治疗前（P＜0.05）；治疗后，治疗组患者的血清GM-CSF、IL-8水平低于对照组，血清IL-2水平高于对照组（P＜0.05）。结论 妇炎康软胶囊联合头孢地尼胶囊治疗慢性盆腔炎具有较好的临床疗效，能减轻患者症状，降低炎症反应。

Objective To investigate the clinical effect of Fuyankang Soft Capsules combined with Cefdinir Capsules in treatment of chronic pelvic inflammatory disease. Methods Patients (104 cases) with chronic pelvic inflammatory disease in Pingdingshan Maternal and Child Health Hospital from August 2020 to June 2022 were divided into control and treatment groups according to the random number table method, and each group had 52 cases. Patients in the control group were po administered with Cefdinir Capsules, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Fuyankang Soft Capsules on the basis of the control group, 6 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the symptom disappearance time, the pelvic effusion and the maximum diameters of inflammatory mass, the serum levels of GM-CSF, IL-8, and IL-2 in two groups were compared. Results After treatment, the total effective rate of the treatment group was 96.15%, and the total effective rate of the control group was 82.69%, and there was a significant difference between two groups (P < 0.05). After treatment, the disappearance times of fever, abdominal pain and abnormal leucorrhea in the treatment group were shorter than those in the control group (P < 0.05). After treatment, the pelvic effusion and the maximum diameter of inflammatory mass in two groups was significantly lower than that before treatment (P < 0.05), and the pelvic effusion and the maximum diameter of inflammatory mass in the treatment group was lower than that in the control group (P < 0.05). After treatment, the serum levels of GM-CSF and IL-8 in two groups were significantly lower than those before treatment, but the serum levels of IL-2 were higher than those before treatment (P < 0.05). After treatment, the serum levels of GM-CSF and IL-8 in the treatment group were lower than those in the control group, but the serum levels of IL-2 were higher than those in the control group (P < 0.05). Conclusion Fuyankang Soft Capsules combined with Cefdinir Capsules has clinical curative effect in treatment of chronic pelvic inflammatory disease, can reduce symptoms and inflammatory reaction of patients.

R984

河南省中医药科学研究专项课题（2022 ZY2067）