阿尔茨海默病是最常见的老年进行性神经退行性疾病，药物治疗是阿尔茨海默病最常用的治疗手段，目前临床上只有少数药物获批。红景天苷是红景天中的主要活性成分，能够通过降低β淀粉样蛋白的神经毒性、抑制神经细胞凋亡、减轻神经细胞氧化应激和炎性损伤、延缓神经元衰老、保护线粒体功能等多种机制发挥防治阿尔茨海默病的作用。因此综述了红景天苷防治阿尔茨海默病的作用机制，为红景天苷的临床研究提供参考。

Alzheimer's disease is the most common progressive neurodegenerative disease in the elderly. Drug treatment is the most commonly used treatment for Alzheimer's disease. At present, only a few drugs have been approved clinically. Salidroside is the main active ingredient in Rhodiolae Crenulatae Radix et Rhizoma. Salidroside can play a role in prevention and treatment of Alzheimer's disease through a variety of mechanisms, such as reducing β amyloid protein neurotoxicity, inhibition of neuronal apoptosis, reduction of oxidative stress and inflammatory damage of neurons, delay of neuronal aging, protection of mitochondrial function, etc. This article reviews the mechanism of salidroside in prevention and treatment of Alzheimer's disease, and provides reference for the clinical research of salidroside.

R971

河北省中医药管理局科研计划项目（2021186）