心力衰竭是常见的临床综合征，其典型特征是高发病率、住院率和死亡率。人参皂苷Rb₁是人参中重要的活性成分之一，可通过抑制心肌细胞凋亡、抑制心肌肥大、调节心肌钙离子浓度、提高心肌抗缺血作用、调节心肌细胞的自噬功能、改善心肌脂肪酸β氧化功能、调控磷脂酰肌醇3-激酶（PI3K）/蛋白质激酶B（Akt）信号通路等多种作用机制对心力衰竭发挥防治作用，总结了人参皂苷Rb₁改善心力衰竭的作用机制，为人参皂苷Rb₁的临床使用提供参考。

Heart failure is a common clinical syndrome, whose typical characteristics are high incidence rate, hospitalization rate, and mortality. Ginsenoside Rb₁ is one of the important active ingredients in Ginseng Radix, and can inhibit cardiomyocyte apoptosis, inhibit myocardial hypertrophy, regulate myocardial calcium concentration, improve myocardial anti ischemic effect, regulate autophagy function of myocardial cells, improve myocardial fatty acids β oxidation function, and regulate PI3K/Akt signal pathway to prevent and treat heart failure through various mechanisms. This paper summarizes the mechanism of ginsenoside Rb₁ in improving heart failure and provides reference for the clinical use of ginsenoside Rb₁.

R972

山东省医药卫生科技发展计划项目（202102080115）