群体感应系统是一种涉及信号分子密度依赖性识别的细胞间交流系统。肺炎链球菌是一种常见的条件致病菌，通常无症状地定植在人类的鼻咽部，当机体免疫力下降时可引起多种疾病。近年来研究表明肺炎链球菌的致病性和耐药性与群体感应有关，提示可以通过群体感应系统对其进行抑制。群体感应抑制剂具有不易诱导抗生素耐药、增强细菌生物膜对抗生素敏感性等优点。概述了肺炎链球菌群体感应系统的调控机制，如通过外排泵基因过表达诱导抗生素耐药、调控毒力因子和调控生物被膜的形成，归纳了植物源性、人工合成的群体感应抑制剂和具有群体感应抑制剂特性的药物3类群体感应抑制剂对肺炎链球菌群体感应系统的抑制作用，为肺炎链球菌群体感应抑制剂的筛选和肺炎链球菌的临床治疗提供参考。

Quorum sensing system is an intercellular communication system involving the density-dependent recognition of signal molecules. Streptococcus pneumoniae is a common opportunistic pathogen, and it is usually colonized in the human nasopharynx asymptomatically which can cause a variety of diseases under hypoimmunity. In recent years, studies have reported the pathogenicity and drug resistance of S. pneumoniae were related to population induction, suggesting that it could be prevented by inhibiting quorum sensing of S. pneumoniae. Quorum sensing inhibitors have the advantages of not easily inducing antibiotic resistance and enhancing the sensitivity of bacterial biofilms to antibiotics. This paper summarizes the regulatory mechanism of quorum sensing system of S. pneumoniae, such as the induction of antibiotic resistance through overexpression of efflux pump gene, regulation of virulence factors, and regulation of biofilm formation, reviews the inhibitory effects of plant-derived quorum sensing inhibitors, synthetic quorum sensing inhibitors, and drugs with the characteristics of quorum sensing inhibitors on the quorum sensing system of S. pneumoniae, providing references for the screening of quorum sensing inhibitors of S. pneumoniae and the clinical treatment of S. pneumoniae.

R978.1

国家自然科学基金资助项目（81860001，82160012，82260001）；海南省重点研发计划国际科技合作项目（GHYF2022011）；海南省重点研发项目（ZDYF2020223）；海南省重大科技专项（ZDKJ2021036）；海南省创新团队项目（820CXTD448）；海南省临床医学中心建设项目基金