目的 探讨芍麻止痉颗粒联合氟哌啶醇片治疗儿童抽动症的临床疗效。方法 选择2020年7月—2022年7月在北京航天总医院治疗的108例抽动症患儿，依据用药差别分为对照组和治疗组，每组各54例。对照组口服氟哌啶醇片，1 mg/次，3次/d；在对照组基础上，治疗组口服芍麻止痉颗粒，5 g/次，3次/d。两组患者经8周治疗。观察两组患者临床疗效，比较治疗前后两组患者症状改善时间，YGTSS、Yale-Brown、CBCL、Piers-Harris和WISC-Ⅳ量表评分，及血清5-羟色胺（5-HT）、神经元特异性醇化酶（NSE）、γ-氨基丁酸（GABA）、谷氨酸（GLU）和多巴胺（DA）水平。结果 治疗后，治疗组总有效率为98.15%，显著高于对照组（83.33%，P＜0.05）。治疗后，治疗组患儿咧嘴、耸肩、挤眼和伸脖子改善时间明显短于对照组（P＜0.05）。治疗后，两组YGTSS、Yale-Brown和CBCL量表评分明显降低，而Piers-Harris和WISC-Ⅳ量表评分均明显升高（P＜0.05），并以治疗组改善更明显（P＜0.05）。治疗后，两组血清5-HT、NSE、GLU、DA水平明显降低，而GABA水平明显升高（P＜0.05），且治疗组改善更明显（P＜0.05）。结论 芍麻止痉颗粒联合氟哌啶醇片治疗儿童抽动症可有效改善患儿症状，促进患儿智力发育，提高自我意识，改善机体神经递质水平。

Objective To explore the clinical effect of Shaoma Zhijing Granules combined with haloperidol in treatment of tourette syndrome in children. Methods Children (108 cases) with tourette syndrome in Beijing Aerospace General Hospital from July 2020 to July 2022 were divided into control and treatment group based on different treatment, and each group had 54 cases. Children in the control group was po administered with Haloperidol Tablets,1 mg/time, three times daily. Children in the treatment group were po administered with Shaoma Zhijing Granules on the basis of the control group, 5 g/time, three times daily. Children in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, and the improvement time of symptom, scale scores of YGTSS, Yale-Brown, CBCL, Piers-Harris and WISC-Ⅳ, and the levels of 5-HT, NSE, GLU, DA, and GABA in two groups before and after treatment were compared.. Results After treatment, the clinical effective rate of the treatment group was 98.15%, which was significantly higher than that of the control group (83.33%, P < 0.05). After treatment, the improvement time of grinning, shrugging, eye squeezing and neck extension in the treatment group was significantly shorter than those in the control group (P < 0.05). After treatment, the scores of YGTSS, Yale-Brown, and CBCL were significantly decreased, while the scores of Piers-Harris and WISC-IV were significantly increased in two groups (P < 0.05), and the improvement was more obvious in the treatment group (P < 0.05). After treatment, the serum levels of 5-HT, NSE, GLU, and DA in two groups were significantly decreased, while the level of GABA was significantly increased (P < 0.05), and the improvement was more obvious in the treatment group (P < 0.05). Conclusion Shaoma Zhijing Granules combined with Haloperidol Tablets in treatment of tourette syndrome in children can effectively improve the symptoms, promote intellectual development, their self-awareness and the level of neurotransmitters.

R971

北京科技计划项目（Z181100001718102）