目的 探究丁苯酞软胶囊联合依达拉奉右莰醇注射用浓溶液治疗急性脑梗死的临床疗效。方法 选取2020年10月—2022年4月六安市中医院收治的72例急性脑梗死患者作为研究对象，将所有患者按照随机数字表法分为对照组和治疗组，每组各36例。对照组静脉滴注依达拉奉右莰醇注射用浓溶液，15 mL加入到100 mL生理盐水中，2次/d。治疗组患者在对照组治疗的基础上口服丁苯酞软胶囊，0.2 g/次，3次/d。两组患者均连续治疗14 d。观察两组的临床疗效，比较两组的美国国立卫生研究院卒中量表（NIHSS）评分、Barthel指数、脑血管储备能力（CVR）、血清单核细胞趋化蛋白-1（MCP-1）、基质金属蛋白酶-9（MMP-9）水平。结果 治疗后，治疗组的总有效率为91.67%，对照组的总有效率为72.22%，组间比较差异具有统计学意义（P＜0.05）。治疗后，两组NIHSS评分降低，Barthel指数升高（P＜0.05），治疗组NIHSS评分低于对照组，Barthel指数高于对照组（P＜0.05）。治疗后，两组CVR升高，搏动指数值降低（P＜0.05），治疗组CVR高于对照组，搏动指数值低于对照组（P＜0.05）。治疗后，两组血清MCP-1、MMP-9水平均降低（P＜0.05），治疗组血清MCP-1、MMP-9水平低于对照组（P＜0.05）。结论 丁苯酞软胶囊联合依达拉奉右莰醇注射用浓溶液能改善急性脑梗死患者神经功能，增加脑血管储备能力，减轻炎症反应，安全性较高，值得推广应用。

Objective To explore the effects of Butylphthalide Soft Capsules combined with Edaravone and Dexborneol Concentrated Solution for injection in treatment of acute cerebral infarction. Methods Patients (72 cases) with acute cerebral infarction in Traditional Chinese Hospital of Lu’an from October 2020 to April 2022 were divided into control and treatment groups according to the random number table method, and each group had 36 cases. Patients in the control group were iv administered with Edaravone and Dexborneol Concentrated Solution for injection, 15 mL added into normal saline 100 mL, twice daily. Patients in the treatment group were po administered with Butylphthalide Soft Capsules on the basis of the control group, 0.2 g/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the NIHSS score, Barthel Index, CVR, and the levels of MCP-1 and MMP-9 in two groups were compared. Results After treatment, the total effective rate of the treatment group was 91.67%, the total effective rate of the control group was 72.22%, and there was a significant difference between two groups (P < 0.05). After treatment, the NIHSS score of two groups were decreased, but the Barthel Index of two groups were increased (P < 0.05). The NIHSS score of the treatment group was lower than that of the control group, but the Barthel Index of the treatment group was higher than that of the control group (P < 0.05). After treatment, the CVR of two groups were increased, but the pulsation index value of two groups were decreased (P < 0.05). The CVR of the treatment group was higher than that of the control group, but the pulsation index value of the treatment group was lower than that of the control group (P < 0.05). After treatment, the serum levels of MCP-1 and MMP-9 in two groups were decreased (P < 0.05), and the serum levels of MCP-1 and MMP-9 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Butylphthalide Soft Capsules combined with Edaravone and Dexborneol Concentrated Solution for injection can improve the neurological function of patients with acute cerebral infarction, increase the cerebrovascular reserve capacity, and reduce the inflammatory response, with high safety, and which is worthy of application.

R971

安徽省医药卫生科技攻关项目（2104h08020246）