肾功能衰竭是各种慢性肾脏病的终末阶段，可发生肾组织进行性不可逆性损伤。丹酚酸B是丹参中主要水溶性化合物，能够抗肾间质纤维化、抗脂质氧化反应、抗炎症反应、改善肾脏血液循环、抗细胞凋亡、抗缺血再灌注损伤、保护血管内皮细胞功能。综述了丹酚酸B防治肾功能衰竭的作用机制，以期为丹酚酸B的临床使用价值提供参考。

Renal failure is the end stage of various chronic kidney diseases, which can cause progressive and irreversible damage to renal tissue. Salvianolic acid B is the main water-soluble compound in Salviae Miltiorrhizae Radix et Rhizoma, which can resist renal interstitial fibrosis, resist lipid oxidation reaction, anti-inflammatory response, improve renal blood circulation, resist apoptosis, resist ischemia-reperfusion injury, and protect vascular endothelial cell function. This paper reviews the mechanism of salvianolic acid B in preventing and treating renal failure, in order to provide reference for the clinical use value of salvianolic acid B.

R965

重庆市科卫联合医学科研项目（2018ZDXM028）