[关键词]
[摘要]
目的 观察清热散结胶囊联合吸入用布地奈德混悬液治疗急性咽炎的临床疗效。方法 选取2021年6月—2022年3月在天津市第五中心医院诊治的90例急性咽炎患者,将入选的患者根据随机数字表法分为对照组和治疗组,每组各45例。对照组患者雾化吸入吸入用布地奈德混悬液,2mg/次,1次/d。治疗组在对照组治疗的基础上口服清热散结胶囊,3粒/次,3次/d。两组患者均连续治疗5d。观察两组的临床疗效,比较两组临床症状缓解情况、血清炎症因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。结果 治疗后,治疗组的总有效率为91.11%,对照组患者的总有效率为71.11%,组间比较差异显著(P<0.05)。治疗后,治疗组患者的咽痛/咽干症状、声音嘶哑、咳嗽消失时间均明显短于对照组(P<0.05)。治疗后,两组血清IL-6、TNF-α水平明显下降(P<0.05),且治疗组血清IL-6、TNF-α水平低于对照组(P<0.05)。结论 清热散结胶囊联合吸入用布地奈德混悬液治疗急性咽炎具有较好的疗效,可迅速缓解症状,降低炎症因子水平,安全有效。
[Key word]
[Abstract]
Objective To observe the clinical efficacy of Qingre Sanjie Capsules combined with Budesonide Suspension for inhalation in treatment of acute pharyngitis. Methods Patients (90 cases) with acute pharyngitis in Tianjin Fifth Central Hospital from June 2021 to March 2022 were divided into control and treatment groups according to random number table method, and each group had 45 cases. Patients in the control group were inhale administered with Budesonide Suspension for inhalation, 2 mg/time, once daily. Patients in the treatment group were po administered with Qingre Sanjie Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and the clinical symptom relief and inflammatory factors (IL-6 and TNF-α) in two groups were compared. Results After treatment, the total effective rate of the treatment group was 91.11%, and the total effective rate of the control group was 71.11%, and there was a significant difference between two groups (P< 0.05). After treatment, disappearance times of sore throat/dry throat symptoms, hoarseness, and cough in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the serum levels of IL-6 and TNF-α in two groups were significantly decreased (P< 0.05), and the serum levels of IL-6 and TNF-α in the treatment group were lower than those in the control group (P < 0.05).Conclusion Qingre Sanjie Capsules combined with Budesonide Suspension for inhalation is effective in the treatment of acute pharyngitis, which can quickly relieve symptoms and reduce the level of inflammatory factors, with good safety.
[中图分类号]
R987
[基金项目]
天津市滨海新区卫计委科技项目(2018BWKY0236)