目的 观察中风回春片联合硫酸氢氯吡格雷片治疗急性脑梗死恢复期的临床疗效。方法 选取2020年3月—2021年8月南阳市第二人民医院收治的120例急性脑梗死恢复期患者，采用随机数字表法将所有患者分为对照组和治疗组，每组各60例。对照组患者口服硫酸氢氯吡格雷片，75mg/次，1次/d。治疗组患者在对照组基础上口服中风回春片，5片/次，3次/d。两组均连续治疗4周。观察两组临床疗效，比较两组的Barthel指数（BI）评分、美国国立卫生研究院卒中量表（NIHSS）评分、血清炎性因子、神经营养指标、神经损伤指标。结果 治疗后，治疗组的总有效率（91.67%）明显高于对照组的总有效率（75.00%），组间比较差异有统计学意义（P<0.05）。治疗后，两组NIHSS评分下降，BI评分升高（P<0.05），且治疗组BI评分高于对照组，NIHSS评分低于对照组（P<0.05）。治疗后，两组血清白细胞介素-17（IL-17）、白细胞介素-1β（IL-1β）、超敏C反应蛋白（hs-CRP）水平均下降，转化生长因子-β（TGF-β）水平均升高（P<0.05），且治疗组血清IL-17、IL-1β、hs-CRP水平低于对照组，TGF-β水平高于对照组（P<0.05）。治疗后，两组血清脑源性神经营养因子（BDNF）、胰岛素样生长因子-1（IGF-1）、碱性成纤维细胞生长因子（bFGF）水平均升高（P<0.05），且治疗组血清BDNF、IGF-1、bFGF水平高于对照组（P<0.05）。治疗后，两组血清血清淀粉样蛋白A（SAA）、心型脂肪酸结合蛋白（H-FABP）、神经损伤指标神经肽Y（NPY）水平均下降（P<0.05），且治疗组血清SAA、H-FABP、NPY水平低于对照组（P<0.05）。结论 中风回春片联合硫酸氢氯吡格雷片治疗急性脑梗死恢复期的疗效显著，可提高患者的生活自理能力，促进其神经功能恢复，调节血清炎性因子、神经营养指标、神经损伤指标水平。

Objective To observe the clinical efficacy of Zhongfeng Huichun Tablets combined with Clopidogrel Bisulfate Tablets in treatment of convalescent acute cerebral infarction. Methods Patients (120 cases) with convalescent acute cerebral infarction in Nanyang Second People’s Hospital from March 2020 to August 2021 were divided into control and treatment groups according to random number table method, and each group had 60 cases. Patients in the control group were po administered with Clopidogrel Bisulfate Tablets, 75 mg/time, once daily. Patients in the treatment group were po administered with Zhongfeng Huichun Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and BI scores, NIHSS scores, serum levels of inflammatory factors, neurotrophic indicators, and nerve injury indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group (91.67%) was significantly higher than that of the control group (75.00%), and the difference was statistically significant between the groups (P < 0.05). After treatment, NIHSS scores in two groups were decreased, but BI scores in two groups were increased (P < 0.05), and BI scores of the treatment group were higher than those of the control group, but NIHSS scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, the serum levels of IL-17, IL-1β, and hs-CRP in two groups were decreased, but the serum levels of TGF-β in two groups were increased (P < 0.05). The serum levels of IL-17, IL-1β, and hs-CRP in the treatment group were lower than those in the control group, but the serum levels of TGF-β in the treatment group were higher than those in the control group (P < 0.05). After treatment, the serum levels of SAA, H-FABP, and NPY in two groups were decreased (P< 0.05), and the serum levels of SAA, H-FABP, and NPY in the treatment group were lower than those in the control group (P < 0.05). Conclusion Zhongfeng Huichun Tablets combined with Clopidogrel Bisulfate Tablets has clinical curative effect in treatment of convalescent acute cerebral infarction, can improve the self-care ability of patients, promote the recovery of neurological function, and regulate the serum levels of inflammatory factors, neurotrophic indicators, and nerve injury indicators.

R971

河南省医学科技攻关计划联合共建立项项目（LHG20201294）