目的 建立血速升颗粒的质量评价方法。方法 采用高效液相色谱法同时测定血速升颗粒中牡荆素葡萄糖苷、牡荆素鼠李糖苷、牡荆素、毛蕊异黄酮葡萄糖苷、芒柄花苷、美迪紫檀素、淫羊藿苷、宝藿苷I、阿魏酸松柏酯、藁本内酯10种成分，并采用化学计量学综合分析数据。结果 10种成分分别在各自范围内线性关系良好（r≥0.999 1），平均回收率在96.86%～100.20%（n＝9）。16批血速升颗粒样品聚为3类；牡荆素鼠李糖苷、藁本内酯、阿魏酸松柏酯、毛蕊异黄酮葡萄糖苷和淫羊藿苷是影响血速升颗粒产品质量的主要成分。结论 熵权优劣解距离（EW-TOPSIS）法结果为生产企业评价产品质量优劣提供了数据支持，所建立的方法可用于血速升颗粒的综合质量评价。

Objective To establish quality evaluation of Xuesusheng Granules. Methods The contents of vitexin-4''-O-glucoside, rhamnosylvitexin, vitexin, calycosin 7-O-β-D-glucopyranoside, ononin, medicarpin, icariin, baohuosideⅠ, coniferyl ferulate, and ligustilide in Xuesusheng Granules were determined by HPLC method. The content data were analyzed by chemometrics method. Results The 10 components had good linear relationships within their respective ranges (r ≥ 0.999 1), and the average recovery rate was 96.86% — 100.20% (n＝9). Statistical analysis showed that 16 batches of samples were clustered into 3 groups. Rhamnosylvitexin, ligustilide, coniferyl ferulate, calycosin 7-O-β-D-glucopyranoside, and icariin were the main potential markers affecting the quality of Xuesusheng Granules. Conclusion The results of EW-TOPSIS method pointed out the data support for the production enterprises to analyze the quality of products. The established method can be used for the comprehensive evaluation of the quality of Xuesusheng Granules.

R286.02

陕西省科技计划项目（2022JQ-898）