目的 探讨颐和春口服液治疗肾阳虚型不育症的临床疗效。方法 选取2019年3月—2020年12月上海市第六人民医院金山分院男科肾阳虚型不育症患者100例，依据随机数字表法将所有患者分为对照组和治疗组，每组各50例。对照组给予常规西医治疗，治疗组在对照组基础上口服颐和春口服液，10 mL/次，3次/d。两组患者连续治疗12周。观察两组的临床疗效，比较精液理化特征指标和生殖激素水平的变化情况。结果 治疗后，治疗组总有效率是84.0%，显著高于对照组的60.0%（P＜0.05）。治疗后，两组精子密度、A级精子密度、A＋B级精子密度均显著高于治疗前（P＜0.05）；治疗后治疗组精子密度、A级精子、A＋B级精子均显著优于对照组（P＜0.05）。治疗后，两组睾酮（T）水平呈现升高趋势，促黄体生成素（LH）、促卵泡激素（FSH）、泌乳素（PRT）均呈现下降趋势（P＜0.05），且治疗后治疗组血清生殖激素水平改善均显著优于对照组（P＜0.05）。结论 颐和春口服液治疗不育症属肾阳虚的患者具有较好的临床疗效，可有效提高精子数量和精子活力，调节患者的血清生殖激素水平，值得临床推广。

Objective To explore the clinical effect of Yihechun Oral Liquid in treatment of kidney Yang deficiency type of infertility.Methods A total of 100 patients with kidney Yang deficiency type of infertility in the Andrology Department of Jinshan Branch of Shanghai Sixth People's Hospital from March 2019 to December 2020 were selected.According to the random number table method,all patients were divided into control group and treatment group,with 50 cases in each group.Patients in the control group were given conventional western medicine treatment.Patients in the treatment group were po administered with Yihechun Oral Liquid on the basis of the control group,10 mL/time,3 times daily.The two groups were treated for 12 weeks.The clinical efficacy of the two groups was observed,and the changes of semen physical and chemical characteristics and reproductive hormone levels were compared.Results After treatment,the total effective rate of the treatment group was 84.0%,which was significantly higher than that of the control group (60.0%,P<0.05).After treatment,the sperm density,grade A sperm density and grade A+B sperm density of the two groups were significantly higher than those before treatment (P<0.05).After treatment,the sperm density,grade A sperm and grade A+B sperm of the treatment group were significantly better than those of the control group (P<0.05).After treatment,the levels of testosterone (T) in the two groups showed an increasing trend,but the levels of luteinizing hormone (LH),follicle stimulating hormone (FSH) and prolactin (PRT) showed a decreasing trend (P<0.05).After treatment,the improvement of serum reproductive hormone levels in the treatment group was significantly better than that in the control group (P<0.05).Conclusion Yihechun Oral Liquid has a good clinical effect in treatment of kidney Yang deficiency type of infertility,and can effectively improve the sperm number and sperm motility,regulate the serum reproductive hormone level of patients,which is worthy of clinical promotion.

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