目的 优化当归挥发油的包合工艺。方法 以藁本内酯包合率、丁烯基苯酞包合率、包合物收率和综合评分为指标，以β-环糊精与挥发油配比、包合温度和包合时间为考察因素，采用Box-Behnken响应面法进行优化，确定了当归挥发油饱和水溶液法包合的最佳工艺条件。结果 优化的包合工艺为β-环糊精与挥发油配比为8∶1、包合温度50 ℃、包合时间60 min。结论 确定的包合工艺包合率、包合物收率较高，工艺稳定可行。

Objective To optimize f inclusion process of Angelica sinensis volatile oil.Methods Taking inclusion rate of ligustilide and 3-butenylphthalide,yield of inclusion compound and comprehensive score as index,β-CD-volatile oil ratio,inclusion temperature,and inclusion times factors as factors,Box-Behnken design-response surface method was used to optimize and confirm the technology of saturated aqueous solution process of Angelica sinensis volatile oil.Results The optimum technological conditions were β-CD-volatile oil ratio 8:1,inclusion temperature 50℃,and inclusion time 60 min.Conclusion The optimal technological conditions have higher inclusion rate and yield,with stable and feasible process.

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山东省重点研发计划(重大科技创新工程)项目(2020CXGC010505);山东省新旧动能转换重大产业攻关项目(鲁动能办[2021]23号);临沂市兰山区科技创新发展计划专项(2026)