骨关节炎是一种慢性退行性关节疾病，也是导致老年人慢性功能障碍的主要因素。二甲双胍是目前公认用于治疗糖尿病的一线药物，可能也对骨关节炎软骨具有保护作用。二甲双胍抑制软骨细胞炎症反应、调节软骨细胞代谢异常、影响软骨细胞分化。对二甲双胍治疗骨关节炎的作用机制做一综述，为二甲双胍临床应用提供参考。

Osteoarthritis is a chronic degenerative joint disease and a major factor to chronic dysfunction in the elderly. Metformin, currently recognized as the first-line drug for treatment of diabetes, may also have protective effects on cartilage in osteoarthritis. Metformin inhibits chondrocyte inflammatory response, regulates abnormal chondrocyte metabolism, and affects chondrocyte differentiation. This article reviews the mechanism of metformin in treatment of osteoarthritis, and provides a reference for the clinical application of metformin.

R966

辽宁省教育厅科学研究经费项目（L202060）