目的 分析替雷利珠单抗不良反应的临床表现和特点，为临床安全用药提供参考。方法 检索中国知网、万方、维普、PubMed、Embase、Web of Science等数据库有关替雷利珠单抗导致不良反应的文献报道，并进行整理分析。结果 共收集到替雷利珠单抗导致不良反应的文献报道17篇，18例患者，其中男性13例（72.2%）、女性5例（27.8%），年龄分布在60岁以上居多（72.2%），发生时间大多在用药后3个月内（72.2%），替雷利珠单抗致不良反应以皮肤及其附件损害最多见（6例，33.3%），17例经停药和对症治疗好转，1例因继发肺部感染死亡。结论 替雷利珠单抗致不良反应累及多个器官/系统，应增强监测，防范严重不良反应的发生，确保用药安全。

Objective The characteristics and relative factors of adverse drug reactions induced by tislelizumab were analyzed, in order to provide reference for the clinical use of tislelizumab properly. Methods Case reports of adverse drug reactions induced by tislelizumab were searched and analyzed from the databases of CNKI, Wanfang, VIP, PubMed, Embase, and Web of Science. Results A total of 17 articles were included with 18 cases, involving 13 males (72.2%) and 5 females (27.8%). The incidence of adverse drug reactions in patients aged over 60 years old was the highest (72.2%), adverse drug reactions induced by tislelizumab frequently occurred within 3 months (72.2%), Organs/systems involved in adverse drug reactions were mainly skin system (6 case, 33.3%). 17 cases were improved after drug withdrawal and symptomatic treatment, and 1 case died due to secondary pulmonary infection. Conclusion Clinicians and pharmacists should pay attention to the adverse drug reactions of tislelizumab, so as to prevent the occurrence of serious adverse drug reactions and ensure the safety of drug use.

R979.1