[关键词]
[摘要]
目的 探讨鹿胎膏联合地屈孕酮片治疗月经不调的临床疗效。方法 选取2021年3月—2022年3月在天津市中心妇产科医院进行治疗的104例月经不调患者为研究对象,依据用药差别将所有患者分为对照组和治疗组,每组各52例。对照组患者口服地屈孕酮片,从月经周期的第11~25天,10 mg/次,2次/d;治疗组患者在对照组基础上口服鹿胎膏,10 g/次,2次/d。两组均治疗2个月经周期。观察两组患者的临床疗效,比较两组相关量表评分、临床症状改善时间、性激素水平。结果 治疗后,治疗组总有效率是98.08%,显著高于对照组的82.69%(P<0.05)。治疗后,两组中华生存质量量表(ChQOL)评分、HPS评分、卡氏功能状态(KPS)评分均较治疗前显著升高,月经失血图(PBAC)评分显著降低(P<0.05);治疗后,治疗组ChQOL评分、HPS评分、KPS评分高于对照组,而PBAC评分低于对照组(P<0.05)。经治疗,治疗组经行腹痛、头晕眼花、腰骶酸软、胃寒肢冷、五心烦热、少言懒语等症状改善时间均显著短于对照组(P<0.05)。治疗后,两组血清卵泡生成激素(FSH)、催乳素(PRL)、黄体生成激素(LH)均较治疗前显著降低,而雌二醇(E2)显著升高,治疗后,治疗组性激素水平改善优于对照组(P<0.05)。结论 鹿胎膏联合地屈孕酮片治疗月经不调具有较好的临床疗效,可有效改善患者临床症状,调整性激素水平,有助于改善患者生活质量,值得临床推广应用。
[Key word]
[Abstract]
Objective To explore the clinical effect of Lutai Ointment combined with dydrogesterone in treatment of irregular menstruation. Methods A total of 104 patients with irregular menstruation treated in Tianjin Central Obstetrics and Gynecology Hospital from March 2021 to March 2022 were selected as the research objects. According to the difference in medication, all patients were divided into control group and treatment group, with 52 cases in each group. Patients in the control group were po administered with Dydrogesterone Tablets, from the 11th to 25th day of the menstrual cycle, 10 mg/time, twice daily. Patients in the treatment group were po administered with Lutai Ointment on the basis of the control group, 10 g/time, twice daily. Both groups were treated for 2 menstrual cycles. The clinical efficacy of the two groups were observed, and the scores of related scales, improvement time of clinical symptoms and sex hormone levels of the two groups were compared. Results After treatment, the total effective rate of treatment group was 98.08%, significantly higher than that of control group 82.69% (P < 0.05). After treatment, the scores of Chinese Quality of Life Scale (ChQOL), HPS and Carsten function status (KPS) in two groups were significantly increased compared with before treatment, while the score of menstrual blood loss map (PBAC) was significantly decreased (P < 0.05). After treatment, ChQOL score, HPS score and KPS score in the treatment group were higher than those in the control group, while PBAC score was lower than that in the control group (P < 0.05). After treatment, the improvement time of symptoms such as abdominal pain, dizziness, lumbosacral softness, stomach cold and limb cold, five upset fever, less speech and lazy language in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, serum follicle-forming hormone (FSH), prolactin (PRL) and luteinizing hormone (LH) in two groups were significantly decreased compared with before treatment, while estradiol (E2) was significantly increased. After treatment, the level of sex hormone in treatment group was better than that in control group (P < 0.05).Conclusion Lutai Ointment combined with dydrogesterone has a significant effect in treatment of irregular menstruation, and can effectively improve the clinical symptoms of patients, adjust the level of sex hormones, help to improve the quality of life of patients, which is worthy of clinical application.
[中图分类号]
R984
[基金项目]
天津市卫生健康科研项目(KJ20047)