竹节香附素A是两头尖中主要含有的三萜皂苷，具有较强的抗肿瘤活性。竹节香附素A可抑制肿瘤细胞增殖，诱导其凋亡和自噬；诱导肿瘤细胞周期阻滞；抑制侵袭和转移；增强肿瘤细胞对化疗药物的敏感性。总结了竹节香附素A的抗肿瘤作用机制，以期为竹节香附素A的开发利用和临床应用提供依据。

Raddeanin A is a main triterpenoid saponin contained in Anemones Raddeanae Rhizoma and has strong anti-tumor activity. Raddeanin A can inhibit tumor cell proliferation, induce apoptosis and autophagy, induce tumor cell cycle arrest, inhibit invasion and metastasis, enhance tumor cell sensitivity to chemotherapeutic drugs. This paper summarizes the anti-tumor mechanism of raddeanin A, in order to provide the basis for the development, utilization, and clinical application of raddeanin A.

R979.1

国家自然科学基金青年基金资助项目(81703582);湖北省自然科学基金资助项目(2016CFB153,2020CFB713);湖北省卫生健康科研基金资助项目(WJ2019M057)