[关键词]
[摘要]
有机阳离子转运体家族是一类位于细胞膜上的功能性膜蛋白,负责转运内源性、外源性阳离子底物,在底物的吸收、分布和排泄过程中发挥着重要作用,其中肝脏、肾脏和消化道处有机阳离子转运体的作用最明显。在疾病状态下有机阳离子转运体的表达和功能会发生改变,会影响底物的体内处置过程,使底物的动力学行为及其效应发生改变。综述了肝脏疾病、肾脏疾病和消化道疾病状态下有机阳离子转运体表达和功能改变对底物体内转运的影响及其生理、药理学意义。
[Key word]
[Abstract]
The family of organic cation transporters (OCTs), located on the cell membrane, is a class of functional membrane proteins and responsible for transporting endogenous/exogenous cation substrates, and play an important role in the absorption, distribution, and excretion of substrates and OCTs account for salient contribution to substrate transport in the liver, kidney, and digestive tract. The expression and function of OCTs, altered in pathological state, can affect the in vivo disposition of substrates and influence the kinetic process and their effects. This review summarizes the impact of changes in the expression and function of OCTs on substrate transport and their physiological/pharmacological significance in the liver, kidney, and digestive tract diseases.
[中图分类号]
R966
[基金项目]
国家自然科学基金资助项目(82173884)