目的 调查2021年遂宁市中心医院住院患者临床应用利伐沙班的合理性，为临床合理用药提供参考。方法 回顾性调查分析遂宁市中心医院2021年1月—12月住院患者使用利伐沙班抗凝的病例共2 405份，对其应用的适应症、禁忌症、用法用量、用药时机、用药疗程、药物转换的合理性进行分析。结果 2 405例应用利伐沙班的病历中，适应症不合理306例，存在用药禁忌84例；2 099例具有应用利伐沙班适应症的病历中，用法用量不合理741例，给药时机不合理15例，疗程不合理31例，药物转换不合理104例。结论 遂宁市中心医院住院患者应用利伐沙班主要存在无适应症用药、用法用量不合理等用药现象，应加强宣教。

Objective To investigate the application of rivaroxaban for inpatients in Suining Central Hospital in 2021, and provide references for clinical rational drug use. Methods A total of 2 405 cases of rivaroxaban anticoagulation in inpatients in Suining Central Hospital from January to December 2021 were retrospectively analyzed, and the indications, contraindications, usage and dosage, timing of administration, duration of administration and rationality of drug conversion were analyzed. Results Among 2 405 cases of rivaroxaban, there were 306 cases of unreasonable indications and 84 cases of contraindication. Among the 2 099 medical records with indications for the use of rivaroxaban, there were 741 cases in unreasonable usage and dosage, 15 cases in unreasonable medication time, 31 cases in unreasonable course of treatment, and 104 cases in unreasonable drug conversion. Conclusion Inpatients using rivaroxaban mainly suffer from irrational use of drugs without indications, unreasonable usage and dosage, etc. Therefore, publicity and education should be strengthened.

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