[关键词]
[摘要]
目的 探讨云芝胞内糖肽胶囊联合双环醇片治疗老年慢性乙型肝炎的临床疗效。方法 选取2020年5月—2021年5月重庆市大足区人民医院接诊治疗的104例老年慢性乙型肝炎患者,根据治疗药物的不同分为对照组和治疗组,每组各52例。对照组口服双环醇片,25 mg/次,3次/d;在此基础上,治疗组口服云芝胞内糖肽胶囊,1 g/次,3次/d。两组患者均连续治疗6个月。观察两组患者临床疗效,比较治疗前后两组患者临床症状改善时间,肝功能丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、白蛋白(ALB)、天氨酸氨基转移酶(AST)、APRI和FIB-4及血清微纤维相关蛋白4(MFAP4)、高尔基体蛋白73(GP73)、结缔组织生长因子(CTGF)、T淋巴细胞免疫球蛋白黏蛋白分子-3(Tim-3)和Mac-2结合蛋白糖基化异构体(M2BPGi)水平。结果 经治疗,治疗组临床有效率为98.08%,显著高于对照组80.77%(P<0.05)。经治疗,治疗组临床症状改善时间优于对照组(P<0.05)。经治疗,两组ALT、TBIL、AST表达均明显降低,而ALB明显升高(P<0.05),且治疗组改善最明显(P<0.05)。经治疗,两组APRI、FIB-4均明显下降(P<0.05),但治疗组下降最明显(P<0.05)。经治疗,两组患者血清MFAP4、GP73、CTGF、Tim-3、M2BPGi表达明显降低(P<0.05),且治疗组下降最明显(P<0.05)。结论 云芝胞内糖肽胶囊联合双环醇片治疗老年慢性乙型肝炎效果明显,可改善患者临床症状,促进患者肝功能恢复,降低纤维化程度,改善血清细胞因子表达。
[Key word]
[Abstract]
Objective To explore the clinical efficacy of Polystictus Glycopeptide Capules combined with Bicyclol Tablets in treatment of elderly chronic hepatitis B. Methods Patients (104 cases) with chronic hepatitis B in the People's Hospital of Dazu, Chongqing from May 2020 to May 2021 were randomly divided into control and treatment group, and each had 52 cases. Patients in the control group were po administered with Bicyclol Tablets, 25 mg/time, three time daily. Patients in the treatment group were po administered with Polystictus Glycopeptide Capules on the basis of the control group, 1 g/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms, liver function indexes ALT, TBIL, AST, ALB, APRI and FIB-4, and the levels of serum MFAP4, GP73, CTGF, Tim-3 and M2BPGi in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 98.08%, which was significantly higher than that of the control group (80.77%) (P < 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was better than that in the control group (P < 0.05). After treatment, the expression of ALT, TBIL and AST were significantly decreased, while ALB were significantly increased in two groups (P < 0.05), and the treatment group improved most obviously (P < 0.05). After treatment, APRI and FIB-4 were significantly decreased in two groups (P < 0.05), but the decrease was the most obvious in the treatment group (P < 0.05). After treatment, the expression of serum MFAP4, GP73, CTGF, Tim-3 and M2BPGi in two groups were significantly decreased (P < 0.05), especially in the treatment group (P <0.05). Conclusion The effect of Polystictus Glycopeptide Capules combined with Bicyclol Tablets in treatment of elderly chronic hepatitis B is obvious, which can improve the clinical symptoms, promote the recovery of liver function, reduce the degree of fibrosis and improve the expression of serum cytokines.
[中图分类号]
R975
[基金项目]
重庆市大足区科技计划项目(DZKJ2019ACC1030)