[关键词]
[摘要]
目的 探讨复方皂矾丸联合琥珀酸亚铁治疗缺铁性贫血的临床效果。方法 选取2019年1月—2021年10月海南医学院第一附属医院收治的116例缺铁性贫血患者,随机分成对照组(58例)和治疗组(58例)。对照组口服琥珀酸亚铁片,2片/次,2次/d。在对照组基础上,治疗组饭后口服复方皂矾丸,8丸/次,3次/d。两组均连续治疗8周。观察两组患者临床疗效,比较治疗前后两组患者主要症状评分,血常规参数血红蛋白(HBG)、平均红细胞血红蛋白量(MCH)、平均红细胞体积(MCV)、红细胞比容(HCT)水平,铁代谢参数血清铁蛋白(SF)和转铁蛋白饱和度(TSAT)水平,及血清可溶性转铁蛋白受体(sTFR)、促红细胞生成素(EPO)、一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平。结果 治疗后,治疗组临床有效率为96.55%,显著高于对照组[86.21%,P<0.05]。治疗后,两组主要症状评分较治疗前均显著减少(P<0.05),且均以治疗组的下降更显著(P<0.05)。与治疗前对比,治疗后两组血常规参数HGB、MCH、MCV、HCT均显著增高(P<0.05),且治疗组的改善更显著(P<0.05)。治疗后,两组SF水平和TSAT均较治疗前显著升高,而血清sTFR、EPO水平则均显著降低(P<0.05),且治疗后,治疗组SF、TSAT、sTFR和EPO水平均显著优于对照组(P<0.05)。治疗后,两组血清NO、TNF-α及IL-6水平均较治疗前显著下降(P<0.05),且治疗后治疗组降低作用较对照组更显著(P<0.05)。结论 复方皂矾丸联合琥珀酸亚铁治疗缺铁性贫血可获得确切疗效,能明显缓解患者贫血症状,改善血常规及铁代谢,并能进一步抑制血清NO、TNF-α和IL-6的表达水平,安全性较高。
[Key word]
[Abstract]
Objective To explore the clinical effect of Compound Zaofan Pills combined with ferrous succinate in treatment of iron deficiency anemia. Methods Patients (116 cases) with iron deficiency anemia in the First Affiliated Hospital of Hainan Medical University from January 2019 to October 2021 were randomly divided into control (58 cases) and treatment (58 cases) group. Patients in the control group were po administered with Ferrous Succinate Tablets, 2 tablets/time, twice daily. Patients in the treatment group were po administered with Compound Zaofan Pills after meals on the basis of the control group, 8 pills/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, the main clinical symptom scores, the levels of blood routine indexes HGB, MCH, MCV, HCT, iron metabolism parameters SF and TSAT, and serum NO, TNF-α and IL-6 levels in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 96.55% (56/58), which was significantly higher than that of the control group[86.21% (50/58), P < 0.05]. After treatment, the scores of main symptoms in two groups were significantly lower than those before treatment (P < 0.05), and the decrease in the treatment group was more significant (P < 0.05). Compared with those before treatment, the blood routine parameters HGB, MCH, MCV and HCT in two groups were significantly increased after treatment, and the improvement in the treatment group was more significant (P < 0.05). After treatment, the levels of SF and TSAT in two groups were significantly higher than those before treatment, while the levels of serum sTFR and EPO were significantly decreased (P < 0.05). After treatment, the levels of SF, TSAT,sTFR and EPO in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the levels of serum NO, TNF-α and IL-6 in two groups were significantly lower than those before treatment (P < 0.05), and the effect of treatment group was more significant than that of control group (P < 0.05). Conclusion Compound Zaofan Pills combined with ferrous succinate in treatment of iron deficiency anemia can obtain definite curative effect, obviously relieve the symptoms of anemia, improve blood routine and iron metabolism, and further inhibit the expression levels of serum NO, TNF- α and IL-6.
[中图分类号]
R973
[基金项目]
吴阶平医学基金会临床科研专项资助(320.3750.18389)