目的 探讨双骨三子胶囊联合骨化三醇治疗女性绝经后骨质疏松性髋部骨折的临床效果。方法 选取2018年3月—2021年3月许昌仁和骨伤医院收治的128例绝经后骨质疏松性髋部骨折患者，随机分成对照组和治疗组，每组各64例。对照组口服骨化三醇软胶囊，1粒/次，2次/d。治疗组在对照组基础上口服双骨三子胶囊，3粒/次，3次/d。两组均连续治疗6个月。观察两组患者临床疗效，比较治疗前后两组患者骨折临床愈合时间，疼痛视觉模拟量表（VAS）评分，36项健康调查简表（SF-36）总分，腰椎正位和髋部的骨密度（BMD），尿钙与尿肌酐比值（U-Ca/Cr）和血清I型前胶原N端前肽（P1NP）、I型胶原羧基末端肽β特殊序列（β-CTX）、白细胞介素（IL）-6水平。结果 治疗后，治疗组临床有效率为93.75%，显著高于对照组的78.12%（P<0.05）。与对照组相比，治疗组骨折临床愈合时间显著缩短（P<0.05）。治疗后，两组疼痛VAS评分均显著降低，而SF-36总分则均显著升高（P<0.05），且治疗组改善更显著（P<0.05）。治疗后，两组腰椎正位和髋部的BMD较治疗前均显著增加（P<0.05），且治疗组比对照组增加更显著（P<0.05）。治疗后，两组U-Ca/Cr和血清β-CTX、IL-6水平较治疗前均显著下降，而血清PINP水平显著上升（P<0.05），且治疗组这些指标比对照组改善更显著（P<0.05）。结论 双骨三子胶囊联合骨化三醇治疗女性绝经后骨质疏松性髋部骨折的总体疗效满意，能安全有效地缓解患者疼痛，促进骨折愈合，增加BMD，改善生活质量。

Objective To investigate the clinical effect of Shuanggu Sanzi Capsules combined with calcitriol in treatment of postmenopausal women with osteoporotic hip fractures. Methods Patients (128 cases) with postmenopausal osteoporotic hip fracture in Xuchang Renhe Bone Injury Hospital from March 2018 to March 2021 were randomly divided into control and treatment group, and each group had 64 cases. Patients in the control group were po administered with Calcitriol Soft Capsules, 1 grain/time, twice daily. Patients in the treatment group were po administered with Shuanggu Sanzi Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical evaluation was evaluated, the fracture healing time, pain VAS score, SF-36 total score, BMD of lumbar vertebrae and hip, U-Ca/Cr and serum PINP, β-CTX and IL-6 levels in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 93.75%, which was significantly higher than that of the control group (78.12%) (P < 0.05). Compared with the control group, the clinical healing time of fracture in the treatment group was significantly shorter (P < 0.05). After treatment, the VAS score in two groups were significantly decreased, while the total score of SF-36 were significantly increased (P < 0.05), and the improvement in the treatment group was more significant (P < 0.05). After treatment, the BMD of lumbar spine and hip in two groups were significantly increased compared with that before treatment (P < 0.05), and the change in the treatment group was more significant than that in the control group (P < 0.05). After treatment, the levels of U-Ca/Cr, serum β-CTX and IL-6 in two groups were significantly lower than those before treatment, while the level of serum PINP was significantly increased (P < 0.05), and these indicators in the treatment group was significantly better than those in the control group (P < 0.05). Conclusion The overall curative effect of Shuanggu Sanzi Capsules combined with calcitriol in treatment of female postmenopausal osteoporotic hip fracture is satisfactory, which can safely and effectively relieve pain, promote fracture healing, increase BMD and improve quality of life.

R977

许昌市科技攻关项目（20190213251）