五味子乙素是五味子中主要活性成分之一,具有多种药理作用。长期研究表明五味子乙素具有保护肝脏、肾脏、肺和心脑血管等作用。五味子乙素的多器官保护作用通过不同的途径起效,作用机制包括抗氧化、抗炎、抗纤维化、促进热休克反应、调节脂质代谢、抑制细胞凋亡。就五味子乙素对各器官的保护作用的分子机制进行了总结,为推进其药理研究和分子机制的阐明以及临床应用提供参考。

Schisandrin B is main active components in Schisandrae Chinensis Fructus, and had various pharmacological effects longterm studies have shown that schisandrin B has the functions of protecting the liver, kidney, lung, cardiovascular and cerebrovascular systems, etc. The organs protective effect of schisandra B works through different pathways, including anti-oxidative effect, antiinflammatory effect, anti-fibrosis, promotion of heat shock response, regulation of lipid metabolism, and inhibition of apoptosis. This paper reviews the protective effect on various systems of molecular mechanism of schisandrin B, and provides a reference for promoting the elucidation of its pharmacology and molecular mechanism and its clinical application.

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国家自然科学基金资助项目(82172822);大连市科技创新基金计划项目(2021JJ13SN60)