目的 探讨西甲硅油联合奥美拉唑治疗儿童功能性消化不良的临床疗效。方法 选取2020年3月-2021年3月郑州大学第三附属医院收治的100例功能性消化不良儿童。随机分为对照组(50例)和治疗组(50例)。对照组餐前30 min口服奥美拉唑肠溶胶囊,0.6~1.0 mg/(kg?d),1次/d。治疗组在对照组基础上口服西甲硅油乳剂,1~2 mL/次,3~5次/d。两组患儿连续用药4周。观察两组患儿临床疗效,比较治疗前后两组患儿临床症状缓解时间和不同时间胃排空率。结果 用药2周后,对照组临床有效率为54.5%,显著低于治疗组的78.3%(P<0.05);用药4周后,对照组临床有效率为68.2%,显著低于治疗组的87.0%(P<0.05)。治疗过程中,治疗组症状缓解时间均明显早于对照组(P<0.05)。治疗2、4周后,两组胃排空率均高于治疗前(P<0.05),治疗组胃排空功能指标较对照组改善更为显著(P<0.05)。结论 西甲硅油联合奥美拉唑能快速改善儿童功能性消化不良,并能持续缓解,安全性及耐受性好。

Objective To investigate clinical effect of simethicone combined with omeprazole in treatment of children with functional dyspepsia.Methods Children (100 cases) with functional dyspepsia in the Third Affiliated Hospital of Zhengzhou University from March 2020 to March 2021 were randomly divided into control (50 cases) and treatment (50 cases) group. Children in the control group were po administered with Omeprazole Enteric-coated Capsules, 0.6 — 1.0 mg/(kg?d), once daily. Children in the treatment group were po administered with Simethicone Emulsion on the basis of the control group, 1 — 2 mL/time, 3 — 5 times/d. Children in two groups were treated for 4 weeks. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms, the gastric emptying rate of different time in two groups before and after treatment were compared.Results After 2 weeks of treatment, the clinical effective rate of control group was 54.5%, significantly lower than 78.3% of treatment group (P < 0.05). After 4 weeks of treatment, the clinical effective rate in control group was 68.2%, significantly lower than 87.0% in treatment group (P < 0.05). During the treatment, the time of symptom relief in the treatment group was significantly earlier than that in the control group (P < 0.05). After 2 and 4 weeks of treatment, the gastric empty-rate in both groups was higher than before (P < 0.05); the improvement of gastric emptying function in the treatment group was more significant than that in the control group (P < 0.05).Conclusion Simethicone Emulsion combined with omeprazole can quickly improve the functional dyspepsia of children, and can continuously relieve with good safety and tolerance.

R975;R985

河南省医学科技攻关计划(联合共建)项目(LHGJ20190404)