目的 探讨仙灵骨葆胶囊联合骨肽片治疗桡骨远端骨折的临床疗效。方法 选取2018年10月-2020年12月在商丘市立医院就诊的106例桡骨远端骨折患者,按照随机数字表法将患者分为对照组和治疗组,每组各53例。对照组患者口服骨肽片,1.2 g/次,3次/d。治疗组患者在对照组基础上口服仙灵骨葆胶囊,1.5 g/次,2次/d。15 d为1个疗程,两组连续治疗2个疗程。观察两组的临床疗效,比较两组患者的主要症状消失时间、疼痛程度和血清因子水平。结果 治疗后,治疗组的总有效率为92.45%,明显高于对照组总有效率77.36%(P<0.05)。治疗后,治疗组的止痛时间、消肿时间、骨折愈合时间明显短于对照组(P<0.05)。治疗后,两组VAS评分显著减小(P<0.05);且治疗组VAS评分明显小于对照组(P<0.05)。治疗后,两组的胰岛素样生长因子-1(IGF-1)、转化生长因子-β₁(TGF-β₁)、血管内皮生长因子(VEGF)水平均明显升高(P<0.05);治疗后,治疗组的IGF-1、TGF-β₁、VEGF水平比对照组高(P<0.05)。结论 仙灵骨葆胶囊联合骨肽片治疗桡骨远端骨折的疗效确切,能促使骨折愈合减轻疼痛程度,调节IGF-1、TGF-β₁、VEGF的分泌,安全性较好。

Objective To investigate the clinical effect of Xianling Gubao Capsules combined with Ossotide Tablets in treatment of distal radius fractures.Methods Patients (106 cases) with distal radius fractures in Shangqiu Municipal Hospital from October 2018 to December 2020 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were po administered with Ossotide Tablets, 1.2 g/time, three times daily. Patients in the treatment group were po administered with Xianling Gubao Capsules on the basis of the control group, 1.5 g/time, twice daily. A course of treatment had15 d, and patients in two groups were treated for 2 courses. After treatment, the clinical efficacies were evaluated, and the disappearance time of main symptoms, the degree of pain, and the serum level of factors in two groups were compared.Results After treatment, the total effective rate of the treatment group was 92.45%, which was significantly higher than 77.36% in the control group (P < 0.05). After treatment, the analgesic time, detumescence time, and fracture healing time in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the VAS score of the two groups were significantly decreased (P < 0.05); the VAS score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the levels of IGF-1, TGF-β1, and VEGF in the two groups were significantly increased (P < 0.05). After treatment, the levels of IGF-1, TGF-β1, and VEGF in the treatment group were higher than those in the control group (P < 0.05).Conclusion Xianling Gubao Capsules combined with Ossotide Tablets is effective in treatment of distal radius fractures, can promote fracture healing, reduce pain, and regulate the secretion of IGF-1, TGF and VEGF, with good safety.

R982

河南省医学科技攻关计划(联合共建项目)(2018020709)