目的 探讨黄葵胶囊联合硫唑嘌呤治疗狼疮性肾炎的临床疗效。方法 选取2019年1月—2021年12月百色市人民医院肾内科治疗的72例狼疮性肾炎患者，按照随机数字表法将所有患者分为对照组和治疗组，每组各36例。对照组患者口服硫唑嘌呤片，100 mg/次，1次/d。治疗组在对照组的治疗基础上口服黄葵胶囊，5粒/次，3次/d。两组均连续治疗8周。观察两组的临床疗效和症状好转时间。比较两组尿蛋白、肾功能指标、血清炎症因子水平。结果 治疗后，治疗组总有效率是97.22%，显著高于对照组的75.00%（P＜0.05）。经治疗，治疗组出现发烧、关节痛、血尿、肢体浮肿等症状好转时间均显著短于对照组（P＜0.05）。治疗后，两组24 h尿蛋白定量（24 h-Upro）、尿微量白蛋白（mALB）、血肌酐（Scr）、血尿素氮（BUN）水平均较治疗前显著降低（P＜0.05）；治疗后，治疗组尿蛋白、肾功能指标改善优于对照组（P＜0.05）。治疗后，两组患者白细胞介素-6（IL-6）、白细胞介素-18（IL-18）、肿瘤坏死因子α（TNF-α）、C反应蛋白（CRP）水平均较治疗前显著降低（P＜0.05）；治疗后，治疗组血清炎症因子低于对照组（P＜0.05）。结论 黄葵胶囊联合硫唑嘌呤治疗狼疮性肾病具有较好的临床疗效，可明显减轻患者临床症状，降低肾功能指标和尿蛋白水平，降低机体炎症反应，值得临床借鉴。

Objective To investigate the clinical effect of Huangkui Capsules combined with azathioprine on lupus nephritis.Methods A total of 72 patients with lupus nephritis treated in the Department of Nephrology, People’s Hospital of Baise from January 2019 to December 2021 were selected, and all patients were divided into control group and treatment group according to random number table method, with 36 cases in each group. Patients in the control group were po administered with Azathioprine Tablets, 100 mg/time, once daily. Patients in the treatment group were po administered with Huangkui Capsules on the basis of the control group, 5 grains/time, three times daily. Both groups were treated for 8 weeks. The clinical efficacy and symptom improvement time of the two groups were observed. The levels of urinary protein and serum factor of renal function were compared between the two groups.Results After treatment, the total effective rate of treatment group was 97.22%, significantly higher than 75.00% of control group (P < 0.05). After treatment, the improvement time of fever, arthralgia, hematuria, limb edema and other symptoms in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the levels of 24 h urinary protein quantification (24 h-Upro), urinary microalbumin (mALB), blood creatinine (Scr) and blood urea nitrogen (BUN) in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, the improvement of urinary protein and renal function in the treatment group was better than that in the control group (P < 0.05). After treatment, the levels of interleukin-6 (IL-6), interleukin-18 (IL-18), tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, serological indexes in the treatment group were lower than those in the control group (P < 0.05).Conclusion Huangkui Capsules combined with azathioprine has good clinical effect in treatment of lupus nephritis, and can significantly reduce the clinical symptoms of patients, reduce renal function indicators and urinary protein levels, and reduce the body’s inflammatory response, which is worthy of clinical reference.

R983

广西壮族自治区卫生健康委员会科研项目(Z20211334)