目的 探讨通窍鼻炎胶囊联合氯雷他定治疗变应性鼻炎的临床疗效。方法 选择2019年2月-2021年2月在郑州市第九人民医院治疗的98例变应性鼻炎患者作为研究对象,按照治疗方式不同分为对照组和治疗组,每组各49例。对照组患者口服氯雷他定片, 1片/次, 1次/d。治疗组在对照组治疗的基础上口服通窍鼻炎胶囊, 2.0 g/次, 3次/d。两组患者的治疗周期均为4周。观察两组患者的临床疗效,比较两组治疗前后的临床症状评分和血清指标。结果 治疗后,治疗组患者的总有效率(95.92%)高于对照组(83.67%),组间比较有差异(P<0.05)。治疗后,两组患者的鼻塞评分、鼻痒评分、喷嚏评分、流涕评分均显著降低,同组比较有显著差异(P<0.05);并且治疗组临床症状评分较对照组降低明显,组间比较有显著差异(P<0.05)。治疗后,两组患者的γ干扰素(IFN-γ)水平明显上升,白细胞介素-17(IL-17)、嗜酸性细胞阳离子蛋白(ECP)、免疫球蛋白E(IgE)水平明显降低,同组治疗前后比较有显著差异(P<0.05);并且治疗组患者的IFN-γ水平较对照组上升明显、IL-17、ECP、IgE水平较对照组降低明显,组间比较有显著差异(P<0.05)。结论 通窍鼻炎胶囊联合氯雷他定片治疗变应性鼻炎具有较好的疗效,可缓解患者临床症状,改善血清指标。

Objective To explore the clinical effect of Tongqiao Biyan Capsules combined with Loratadine Tablets in treatment of allergic rhinitis.Methods Patients (98 cases) with allergic rhinitis in Ninth People’s Hospital of Zhengzhou from February 2019 to February 2021 were divided into control and treatment groups according to the treatment method, and each group had 49 cases. Patients in the control group were po administered with Loratadine Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Tongqiao Biyan Capsules on the basis of the control group, 2.0 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the clinical symptom scores and serum indexes in two groups were compared before and after treatment.Results After treatment, the total effective rate of the treatment group (95.92%) was higher than that of the control group (83.67%) (P < 0.05). After treatment, the scores of nasal obstruction, nasal itching, sneezing and runny nose in two groups were significantly lower than those in the same group (P < 0.05), and these scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of IFN-γ in two groups were significantly increased, but the levels of IL-17, ECP, and IgE in two groups were significantly decreased (P < 0.05), and the levels of serum indexes in the treatment group were significantly better than those in the control group (P < 0.05).Conclusion Tongqiao Biyan Capsules combined with Loratadine Tablets in treatment of allergic rhinitis has better therapeutic effect, can alleviate patients’ clinical symptoms and improve serum indexes.

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国家自然科学基金资助项目(81804057)