目的 分析贝伐珠单抗不良反应（ADR）发生率、发生类型和严重程度，为临床安全合理使用提供参考。方法 采用文献计量分析的方法，以“贝伐珠单抗”“安维汀”“阿瓦斯汀”“avastin”“bevacizumab”“不良反应”“副作用”“adverse reaction”为关键词，检索万方、中国知网、维普、PubMed、SpringerLink数据库，采用Excel软件建立数据库，对ADR的类型、发生率及占比进行统计分析。结果 共纳入文献171篇，1 024例患者共出现1 634例贝伐珠单抗ADR。最常见的ADR类型为骨髓抑制、高血压、蛋白尿、出血；严重程度较高的ADR为动静脉栓塞、消化道穿孔、癫痫等。结论 临床医师或药师在应用贝伐珠单抗治疗相关疾病时，应重视其常见及严重的ADR。

Objective To analyze the incidence, types, and severity of adverse reactions (ADR) of bevacizumab, and to provide reference for safe and rational clinical use. Methods Using the method of bibliometric analysis, keywords "bevacizumab" "avastin" "avastin" "bevacizumab" "adverse reaction" "side effect" and "adverse reaction" were selected. The databases of Wanfang, CNKI, VIP, PubMed, and SpringerLink were searched, and excel software was used to establish the database. Types, incidence, and proportion of ADR were statistically analyzed. Results 171 related articles were finally included involving a total of 1 024 subjects and 1 634 cases of ADR. The most common ADR of bevacizumab included bone marrow suppression, hypertension, proteinuria, bleeding, etc. ADR with high severity include arteriovenous embolism, gastrointestinal perforation, epilepsy and so on. Conclusion Clinicians or pharmacists should pay attention to the common and serious ADR of bevacizumab in treatment of related diseases, and actively and correctly intervene the serious ADR.

R979.1