[关键词]
[摘要]
目的 探讨雷公藤多苷片联合西替利嗪治疗泛发性湿疹的临床疗效。方法 选取2018年5月—2021年6月昆山市第一人民医院收治的118例泛发性湿疹患者,按照随机数字表法将118例患者随机分成对照组和治疗组,每组各59例。对照组口服盐酸西替利嗪片,10 mg/次,1次/d。治疗组在对照组基础上口服雷公藤多苷片,1.0 mg/kg,分3次于早、中、晚餐后服用。两组均连续治疗4周。观察两组的临床疗效,比较两组湿疹面积及严重度指数(EASI)评分、瘙痒视觉模拟量表(VAS)评分、湿疹生活质量量表(EQOLS)评分、外周血嗜酸性粒细胞(EOS)计数及血清一氧化氮(NO)、白细胞介素(IL)-10、IL-17水平。结果 治疗后,治疗组总有效率是91.5%,显著高于对照组的78.0%(P<0.05)。治疗后,两组EASI中皮损症状、皮损面积评分及总分和瘙痒VAS评分均较治疗前显著降低(P<0.05);且均以治疗组下降更显著(P<0.05)。治疗后,两组EQOLS中各维度(疾病、生理、心理、社会)评分及总分较治疗前均显著下降(P<0.05);且均以治疗组改善更显著(P<0.05)。与治疗前对比,两组治疗后外周血EOS计数及血清NO、IL-10、IL-17水平均显著下降(P<0.05);且治疗后,治疗组外周血EOS计数和血清学因子低于对照组(P<0.05)。结论 雷公藤多苷片联合西替利嗪治疗泛发性湿疹具有较好的临床疗效,能有效缓解患者临床症状,调节机体免疫状态,抑制体内炎症反应,提高生活质量,且安全性较好,值得临床推广。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Tripterygium Glycosides Tablets combined with cetirizine in treatment of generalized eczema. Methods A total of 118 patients with generalized eczema admitted to Kunshan First People's Hospital from May 2018 to June 2021 were selected, and they were randomly divided into control group and treatment group according to random number table method, with 59 cases in each group. Patients in the control group were po administered with Cetirizine Hydrochloride Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Tripterygium Glycosides Tablets on the basis of the control group, 1.0 mg/kg, they took it three times after breakfast, lunch and dinner. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, eczema area and severity index (EASI) score, visual analog scale (VAS) score, eczema quality of life scale (EQOLS) score, peripheral blood eosinophilia (EOS) count, and serum nitric oxide (NO), interleukin (IL)-10 and IL-17 levels were compared between the two groups. Results After treatment, the total effective rate in treatment group was 91.5%, significantly higher than 78.0% in control group (P < 0.05). After treatment, EASI symptoms score, EASI area score, total scores, and pruritus VAS scores in two groups were significantly decreased compared with before treatment (P< 0.05). The decrease was more significant in the treatment group (P< 0.05). After treatment, EQOLS scores of various dimensions (disease, physiological, psychological and social) and total scores in both groups were significantly decreased compared with those before treatment (P < 0.05). The improvement was more significant in the treatment group (P< 0.05). Compared with before treatment,peripheral blood EOS count and serum NO, IL-10 and IL-17 levels in two groups were significantly decreased after treatment (P < 0.05). After treatment, the peripheral blood EOS count and serological factors in the treatment group were lower than those in the control group (P< 0.05). Conclusion Tripterygium Glycosides Tablets combined with cetirizine has good clinical effect in treatment of generalized eczema, and can effectively relieve the clinical symptoms of patients, regulate the immune state of the body, inhibit the inflammatory response in the body, improve the life quality with good safety, which is worthy of clinical promotion.
[中图分类号]
R986
[基金项目]
昆山市科学技术局科技计划项目(KS19058)